Results 141 to 150 of about 85,064 (291)

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Season-Aware Aminotransferase Interpretation in Type 2 Diabetes: Response to Dai and Wang. [PDF]

Liver Int
Toki R, Sakamoto M.
europepmc   +1 more source

Aspartate Aminotransferase, Cytoplasmic [PDF]

, 2020
openaire   +1 more source

Mapping multi-substrate specificity of Arabidopsis aminotransferases

Nitrogen is an essential element in all organisms, and its availability and use efficiency directly impact organismal growth and performance, especially in plants.
V., M., Rhee, S., Huß, S., Maeda, H., Nikoloski, Z. ; https://orcid.org/, de Oliveira, Koper, K., Hataya, S., Soleymani Babadi, F. ; https://orcid.org/, Takasuka, T., Hawkins, C.   +10 more
core   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

Within-Person Seasonal Variability of Aminotransferases and Long-Term Glycemic Control in Adults With Type 2 Diabetes (JDDM 85). [PDF]

Liver Int
Toki R, Sakamoto M, Yuki M, Iida M, Yamazaki M, Ichikawa S, Horiuchi R, Maegawa H, Okamura T, Takebayashi T.   +9 more
europepmc   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

Effects of SGLT-2 inhibitors and GLP-1 receptor agonists on liver function in patients with non-alcoholic fatty liver disease and type 2 diabetes. [PDF]

Front Endocrinol (Lausanne)
Guo W, Li W, Li X, Shi W, Yan Y, Yan T, Zhou J, Huang Y.   +7 more
europepmc   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source