Results 191 to 200 of about 221,538 (343)

Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček   +3 more
wiley   +1 more source

Methylophiopogonanone a attenuates pulmonary fibrosis by inhibiting SPP1‐mediated macrophage polarization via the PI3K/Akt pathway

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Transcriptome sequencing identified secreted phosphoprotein 1 (SPP1) as a crucial target through which methylophiopogonanone A (MOA) ameliorates pulmonary fibrosis. Molecular docking and microscale thermophoresis (MST) assays confirmed a favorable binding affinity between MOA and SPP1.
Fan Yang   +10 more
wiley   +1 more source

Effects of Ethanolic Leaves Extract of Irvingia gabonensis on Arsenic Trioxide-Induced Liver damage in Wistar rats

open access: yesJournal of Applied Sciences and Environmental Management
The toxicity of drugs and other related agents attracts considerable attention from basic scientists to clinicians. Humankind has been passionate about the availability of cheap and readily available agent against organotoxicity.
S. B. Olukayode, S. O. Innih
doaj  

The Role of Low-Protein and Cassava-Cyanide Intake in the Aetiology of Tropical Pancreatitis [PDF]

open access: yes, 2008
Anoruo, K.   +3 more
core  

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