Results 191 to 200 of about 13,961 (264)

The Silent Face of Chronic Hepatitis B: Biopsy-Supported Fibrosis Detection and the Reliability of Non-Invasive Scores (FIB-4, APRI) in Inactive, Gray Zone, and Immune-Tolerant Cases. [PDF]

Med Sci Monit
Aydın MK.
europepmc   +1 more source

Nine‐Year Follow‐Up After M‐TEER for Secondary Mitral Regurgitation in a Patient With Cardiogenic Shock

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Transcatheter edge‐to‐edge repair (TEER) has become an established therapeutic option for patients with severe secondary mitral regurgitation (SMR). While randomized trials and registry data have reported outcomes up to 5 years, longer follow‐up data remain scarce.
Tobias Reithmayer, Thomas J. Stocker, Ludwig T. Weckbach, Julia Novotny, Philipp M. Doldi, Hannah Kempton, Steffen Massberg, Michael Näbauer, Jörg Hausleiter, Lukas Stolz   +9 more
wiley   +1 more source

Case Report: Elevated Aminotransferases and Altered Hepatic Perfusion due to Retroperitoneal Paraganglioma. [PDF]

GE Port J Gastroenterol
Freitas GM, Heringer CT, Dos Santos ÉL, de Souza CO, Pereira Soares SR, Wahle RC.   +5 more
europepmc   +1 more source

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

Repeated Cold Water Stress Leads to Improvements in Mitochondrial Metabolism of Skeletal Muscles in Rats. [PDF]

Metabolites
Bosiacki M, Tarnowski M, Panczyk M, Lubkowska A.   +3 more
europepmc   +1 more source

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Late-onset combined immunodeficiency and bone marrow failure in severe autoimmune hepatitis: a case report. [PDF]

J Med Case Rep
Sahbani F, Hajer H, Zehani A, Dabbebi H, Yacoub H, Cherif D, Maamouri N, Kchir H.   +7 more
europepmc   +1 more source

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

Transition from zinc salts to trientine tetrahydrochloride in a cohort of adult patients with Wilson disease: the ZICUP study. [PDF]

Orphanet J Rare Dis
Poujois A, Obadia MA, Oussedik-Djebrani N, Couchonnal-Bedoya E, Ory-Magne F, Debray D.   +5 more
europepmc   +1 more source

Hypocholesterolaemia as an early feature of presumed acute fatty liver of pregnancy. [PDF]

Obstet Med
Nik Ghazali NNI, Pavey J, Morton A.
europepmc   +1 more source