Results 291 to 300 of about 21,862 (343)

Jordans' anomaly in Chanarin-Dorfman syndrome. [PDF]

Adv Lab Med
Sánchez-Cortés J, Gabaldó-Barrios X.
europepmc   +1 more source

Single‐component cationic polyethylenimine thermogel for sustained and localized gene delivery to combat multi‐drug resistant cancer

BMEMat, EarlyView.
A cationic thermogelling copolymer employing branched PEI‐25 kDa as the sole hydrophilic segment can be facilely complexed with plasmid by physical mixing in the sol phase. Spontaneous gelation is achieved via self‐assembly after injection due to physiological temperature. Sustained and localized release of plasmid from the cationic PEI‐thermogel leads
Qianyu Lin, Minting Liu, Lingjie Ke, Nicholas Wei Xun Ong, Joey Hui Min Wong, Cally Owh, Valerie Ow, Belynn Sim, Yi Jian Boo, Jason Y. C. Lim, Yunlong Wu, Xian Jun Loh   +11 more
wiley   +1 more source

Naringin in cholestatic liver ischemia-reperfusion injury. [PDF]

Acta Cir Bras
Aslaner A, Eyvaz K, Aydemir E, Yıldırım Ş, Kartal KK, Ellidağ HY, Doğan U.   +6 more
europepmc   +1 more source

Multifunctional liposomes remodeling tumor microenvironment for enhancing Hemoporfin‐mediated photodynamic therapy

BMEMat, EarlyView.
BSO/CAT@Liposomes‐Hemoporfin nanoparticles could significantly enhance the ROS levels in cells in vitro and tumor model in vivo, which is attributed to the increasement of Hemoporfin in the tumor, depletion of GSH, and enhancement of local oxygen concentration.
Yawen Chen, Chenxi Wang, Jiajia Yin, Xuejiao Song, Xiaochen Dong, Yi Shen, Lothar Lilge, Buhong Li   +7 more
wiley   +1 more source

Synthesis of β-Alanine From Isoleucine and Propionate Catabolism via Aminotransferases. [PDF]

Plant Direct
Goldfarb MH, Boesel J, Wilczewski-Shirai KC, Reinhart P, Scherger T, Webb C, Newlun M, Rouhier KA.   +7 more
europepmc   +1 more source

N‐1 semi‐continuous transient perfusion in shake flask for ultra‐high density seeding of CHO cell cultures in benchtop bioreactors

Biotechnology Progress, EarlyView.
Abstract One strategy to enhance the production of biological therapeutics is using transient perfusion in the preculture (N‐1 stage) to seed the production culture (N stage) at ultra‐high cell densities (>10 x 106 viable cells/mL). This very high seeding density improves cell culture performance by shortening the timeline and/or achieving higher final
Lucas Lemire, Sebastian‐Juan Reyes, Yves Durocher, Robert Voyer, Olivier Henry, Phuong Lan Pham   +5 more
wiley   +1 more source

Acute Transient Aminotransferase Elevation is Common With Intrathecal Methotrexate, but Liver Injury is Infrequent. [PDF]

Liver Int
Gopalakrishna H, Hercun J, Shah NN, Roschewski M, Rotman Y.   +4 more
europepmc   +1 more source

A phase II basket trial of dual anti‐CTLA‐4 and anti‐PD‐1 blockade in rare tumors (DART) SWOG S1609: durable responses and delayed pseudoprogression in small cell carcinoma of the ovary, hypercalcemic type cohort

Cancer Communications, EarlyView.
Abstract Background The combined use of anti‐programmed cell death protein 1 (PD‐1)/anti‐cytotoxic T‐lymphocyte associated protein 4 (CTLA‐4) checkpoint inhibitors has been effective in various cancer types. The Southwest Oncology Group (SWOG) Dual Anti‐CTLA‐4 and Anti‐PD‐1 Blockade in Rare Tumors (DART) S1609 study investigated ipilimumab and ...
Young Kwang Chae, Megan Othus, Sandip Pravin Patel, Raid Aljumaily, Khine Z. Win, Tanya Pejovic, Sajeve S. Thomas, William R. Robinson III, Hye Sung Kim, Liam Il‐Young Chung, Christine M. McLeod, Helen X. Chen, Elad Sharon, Howard Streicher, Christopher W. Ryan, Charles D. Blanke, Razelle Kurzrock   +16 more
wiley   +1 more source

The Neurometabolic Function of the Dopamine-Aminotransferase System. [PDF]

Metabolites
Apryatin SA.
europepmc   +1 more source

First‐line serplulimab plus chemotherapy in extensive‐stage small‐cell lung cancer: Updated results and biomarker analysis from the ASTRUM‐005 randomized clinical trial

Cancer Communications, EarlyView.
Abstract Background The ASTRUM‐005 study previously demonstrated a significant overall survival (OS) benefit with serplulimab (a programmed death 1 inhibitor) plus chemotherapy versus chemotherapy alone in previously untreated extensive‐stage small‐cell lung cancer (ES‐SCLC).
Ying Cheng, Shuang Zhang, Liang Han, Lin Wu, Jun Chen, Peiyan Zhao, Hongmei Sun, Guilan Wen, Yinghua Ji, Anastasia Zimina, Jianhua Shi, Zhijie Pan, Jinsheng Shi, Xicheng Wang, Yuansong Bai, Tamar Melkadze, Yueyin Pan, Xuhong Min, Maksym Viguro, Xingya Li, Yanqiu Zhao, Junquan Yang, Tamta Makharadze, Ekaterine Arkania, Haoyu Yu, Jing Li, Fang Yang, Xinyi Yang, Chen Ling, Qingyu Wang, Yongqiang Shan, Jun Zhu, the ASTRUM‐005 Study Group   +32 more
wiley   +1 more source