Results 71 to 80 of about 9,258 (171)

Insufficient or Excessive Niacin Intake Induced Glucose and Lipid Metabolic Disorders and Impaired Liver Health in Nile Tilapia

open access: yesAquaculture Nutrition, Volume 2026, Issue 1, 2026.
Niacin (vitamin B3) is involved in the metabolic regulation of energy metabolism in animals. However, both deficiency and excess supplementation of niacin can induce profound physiological disturbances in fish. The present study investigated the effect of niacin on energy metabolism and liver health in Nile tilapia (Oreochromis niloticus).
Ruixin Li   +11 more
wiley   +1 more source

Induction of hyperammonia in irradiated hepatoma cells: a recapitulation and possible explanation of the phenomenon [PDF]

open access: yes, 2004
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J van Rijn   +12 more
core   +1 more source

Endosymbiosis in trypanosomatids: the genomic cooperation between bacterium and host in the synthesis of essential amino acids is heavily influenced by multiple horizontal gene transfers [PDF]

open access: yes, 2013
Background Trypanosomatids of the genera Angomonas and Strigomonas live in a mutualistic association characterized by extensive metabolic cooperation with obligate endosymbiotic Betaproteobacteria.
Alves, João M.P.   +10 more
core   +5 more sources

Valproate induces the unfolded protein response by increasing ceramide levels [PDF]

open access: yes, 2016
Bipolar disorder (BD), which is characterized by depression and mania, affects 1–2% of the world population. Current treatments are effective in only 40–60% of cases and cause severe side effects.
Cottier, Stéphanie   +5 more
core   +1 more source

Genomic Inference of the Metabolism and Evolution of the Archaeal Phylum Aigarchaeota [PDF]

open access: yes, 2018
Microbes of the phylum Aigarchaeota are widely distributed in geothermal environments, but their physiological and ecological roles are poorly understood.
Castelle, Cindy J.   +14 more
core   +3 more sources

In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System [PDF]

open access: yes, 2016
Accurate prediction of the potential hepatotoxic nature of new pharmaceuticals remains highly challenging. Therefore, novel in vitro models with improved external validity are needed to investigate hepatic metabolism and timely identify any toxicity ...
Damm, Georg   +11 more
core   +2 more sources

p-Cresyl sulfate [PDF]

open access: yes, 2017
If chronic kidney disease (CKD) is associated with an impairment of kidney function, several uremic solutes are retained. Some of these exert toxic effects, which are called uremic toxins.
Glorieux, Griet   +3 more
core   +3 more sources

Orotic Aciduria [PDF]

open access: yes, 2018
Orotic acid is an intermediate found in the pathway for pyrimidine synthesis. The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes the production of orotic acid by the conversion of the compound dihydroorotate to orotic acid.
Fonteh, Aliah L
core   +1 more source

Ammonia toxicity to the brain [PDF]

open access: yes, 2018
Hyperammonemia can be caused by various acquired or inherited disorders such as urea cycle defects. The brain is much more susceptible to the deleterious effects of ammonium in childhood than in adulthood.
Braissant, Olivier   +2 more
core  

Genetic engineering possibilities for CELSS: A bibliography and summary of techniques [PDF]

open access: yes
A bibliography of the most useful techniques employed in genetic engineering of higher plants, bacteria associated with plants, and plant cell cultures is provided. A resume of state-of-the-art genetic engineering of plants and bacteria is presented. The
Johnson, E. J.
core   +1 more source

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