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Metabolic coupling between glutamate and N-acetylaspartate in the human brain. [PDF]
J Cereb Blood Flow MetabHong S, Tomar JS, Shen J.
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C1ql1 expression in oligodendrocyte progenitor cells promotes oligodendrocyte differentiation. [PDF]
FEBS JAltunay ZM +15 more
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Purification and preliminary characterization of brain aspartoacylase
Archives of Biochemistry and Biophysics, 2003Aspartoacylase catalyzes the deacetylation of N-acetylaspartic acid (NAA) in the brain to produce acetate and L-aspartate. An aspartoacylase deficiency, with concomitant accumulation of NAA, is responsible for Canavan disease, a lethal autosomal recessive disorder.
Roger A, Moore +3 more
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Expression of aspartoacylase (ASPA) and Canavan disease
Gene, 2012Canavan disease (CD) is a neurodegenerative disorder usually presenting in the first six months of life. CD patients can be identified via elevated levels of N-acetyl-l-aspartate in the pattern of urinary organic acids assessed by gas chromatography-mass spectrometry.
Sommer, Anke, Saß, Jörn-Oliver
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Modeling the Complete Catalytic Cycle of Aspartoacylase
The Journal of Physical Chemistry B, 2016The complete catalytic cycle of aspartoacylase (ASPA), a zinc-dependent enzyme responsible for cleavage of N-acetyl-l-aspartate, is characterized by the methods of molecular modeling. The reaction energy profile connecting the enzyme-substrate (ES) and the enzyme-product (EP) complexes is constructed by the quantum mechanics/molecular mechanics (QM/MM)
Ekaterina D, Kots +5 more
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