Results 71 to 80 of about 583,468 (318)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Domain adaptive English aspect word extraction method based on bidirectional long and short-term memory network and multi-head attention mechanism

Journal of Applied Science and Engineering
English aspect word extraction is a core task of aspect level sentiment analysis. With the continuous development of social networks, more users tend to make decisions based on comment text, and pay more attention to the details of comment text ...
Tianxiao Wang
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

OBOME - Ontology based opinion mining in UBIPOL [PDF]

, 2012
Ontologies have a special role in the UBIPOL system, they help to structure the policy related context, provide conceptualization for policy domain and use in the opinion mining process.
Husani, M, Ko, A, Kocyigit, A, Lee, H, Tapucu, D   +4 more
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Quantifying Review Informativeness With Aspect-Aware Knowledge Graphs and Linguistic Parsing

IEEE Access
The increasing reliance on user reviews for decision-making has elevated the role of online reviews on e-commerce platforms, yet the surge in generic, vague, or promotional content undermines their informativeness and credibility.
Rania A. AlQadi, Shereen A. Taie, Asmaa Hashem Sweidan, Esraa Elhariri   +3 more
doaj   +1 more source

Froth flotation and Kimberley, B.C. the role of technology in the transition between mining camp and community [PDF]

, 2010
Throughout the industrial age, the search for mineral resources has led to the creation of many temporary resource extraction settlements, the vast majority of which never become long-term communities. For those who do, there is a critical point at which

core  

Stern-Gerlach splitting of low-energy ion beams

, 2019
We present a feasibility study with several magnetic field configurations for creating spin-dependent forces that can split a low-energy ion beam by the Stern-Gerlach effect.
Folman, Ron, Henkel, Carsten, Jacob, Georg, Japha, Yonathan, Keil, Mark, Schmidt-Kaler, Ferdinand, Stopp, Felix   +6 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source