Results 221 to 230 of about 216,445 (311)

Regression of a Cardiac Calcified Amorphous Tumor Under Antiplatelet Therapy in a Patient With Ischemic Stroke: A Case Report and Literature Review. [PDF]

Cureus
Matsueda S, Makino R, Nagano Y, Higa N, Tanaka S, Yamahata H, Hanaya R.   +6 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Chemopreventive Effects of Statins and Aspirin on Colorectal Cancer Among Patients with Inflammatory Bowel Disease: Evidence of a Synergistic Association from a Large Cohort. [PDF]

Clin Exp Gastroenterol
Sleiman J, Khouri C, Lee UJ, Dimachkie R, Abureesh O, Njeim R, Deeb L.   +6 more
europepmc   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

Retraction: Phospho-Aspirin-2 (MDC-22) Inhibits Estrogen Receptor Positive Breast Cancer Growth Both In Vitro and In Vivo by a Redox-Dependent Effect. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Association of prehospitalization aspirin therapy and acute lung injury: Results of a multicenter international observational study of at-risk patients*

, 2011
Daryl J. Kor, Jason Erlich, Michelle N. Gong, Michael Malinchoc, Rickey E. Carter, Ognjen Gajic, Daniel Talmor   +6 more
openalex   +2 more sources

Compact Optical Reservoir Computing via Luminescence Dynamics in Rare‐Earth Ions‐Doped Nanocrystals

Advanced Science, EarlyView.
A functionally compact optical reservoir computing platform is demonstrated using rare‐earth ion‐doped nanocrystals, whose intrinsic nonlinear luminescence dynamics and multi‐timescale metastable states provide nonlinear mapping and fading memory without bulky delays or resonant structures.
Junyan Chen, Jingsong Fu, Jie Xu, Yixiang Qin, Axin Du, Kaiyang Wang, Limin Jin, Can Huang   +7 more
wiley   +1 more source

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

Comparative Effectiveness of Aspirin and Low-molecular-weight heparin for Venous Thromboembolism Prophylaxis after Total Hip Arthroplasty. [PDF]

J Orthop Case Rep
Shahzad A, Ali HB, Nikose S, Shah SAA, Shami AM, Jamil W.   +5 more
europepmc   +1 more source

Real‐Time High‐Definition Hyperspectral Endoscopy via Spatial‐Temporal Low‐Frequency‐Stochastic Spectral Encoding

Advanced Science, EarlyView.
A real‐time, high‐definition hyperspectral endoscopy is enabled by developing a spatial‐temporal spectral encoding approach based on low‐frequency stochastic filters combined with an encoding‐guided attention network. It provides hyperspectral image of in vivo tissue with fine superficial features, enables visualization of rapid and subtle ...
Xiaowei Liu, Jiakang Shao, Julin Xiao, Chenying Yang, Jiahe Zhang, Xiaoyu Yang, Xiang Hao, Ying Gu, Xu Liu, Yizhou Tan, Ji Qi, Qing Yang   +11 more
wiley   +1 more source