Results 201 to 210 of about 239,825 (303)

Bridging Chemical Literature and Molecular Graphs: LLM‐Augmented Enantioselectivity Prediction for Iridium‐Catalyzed Asymmetric C–H Borylation

Advanced Science, EarlyView.
A machine‐learning framework for asymmetric C–H borylation bridges multi‐entity 3D molecular graphs and chemical literature. Atom‐resolved mechanistic annotations extracted by large language models augment three‐component graph encoding of catalyst, substrate, and product. The model predicts enantioselectivity with high accuracy on unseen scaffolds and
Zhe Wang, Baohua Zhang, Yi Isaac Yang, Yuan Yao, Yinwu Li   +4 more
wiley   +1 more source

Efficacy of Biologics in Aspirin Exacerbated Respiratory Disease. [PDF]

Clin Transl Allergy
Priessnitz JK, Hagopian A, Patev AJ, Han JK, Lam KK.   +4 more
europepmc   +1 more source

Balancing Crystallization Kinetics and Lattice Strain Enables Thermally Stable Slot‐Die‐Coated Narrow‐Bandgap Perovskite Solar Cells

Advanced Science, EarlyView.
Unbalanced crystallization in mixed Sn‐Pb perovskites causes film defects and instability. CsPbI3 nanocrystals serve as nucleation seeds to regulate growth during slot‐die coating. Resulting solar cells retain 80% efficiency after nine thermal cycles. Operando GIWAXS confirms suppressed microstrain and lattice distortion, demonstrating that synergistic
Xiaojing Ci, Altantulga Buyan‐Arivjikh, Xiongzhuo Jiang, Simon A. Wegener, Christoph G. Lindenmeir, Lixing Li, Thomas Baier, Matthias Schwartzkopf, Sarathlal Koyiloth Vayalil, Kun Sun, Peter Müller‐Buschbaum   +10 more
wiley   +1 more source

Targeting cGAS-STING and Ferroptosis in Aortic Disease: Another Aspirin Discovery. [PDF]

Arterioscler Thromb Vasc Biol
Owens AP, Benson TW.
europepmc   +1 more source

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Platelet count polygenic scores may modify the effect of aspirin in primary prevention of dementia. [PDF]

Alzheimers Dement
Fransquet PD, Yu C, Tran C, Hussain SM, Brodtmann A, Tonkin AM, Nelson MR, Ryan J, McNeil JJ, Lacaze P.   +9 more
europepmc   +1 more source

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

Advanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou, Chen‐Hao Xu, Bo‐Wei Li, Leung Chan, Yi‐Di Xu, Han‐Bo Su, Rui Peng, Fang‐Ji Luo, Ya‐Chen Peng, Zhen‐Yan Li, Vincent Kam Wai Wong, Xiao‐Fei Zheng, Xing Ma, Zhen‐Gang Zha, Tianfeng Chen, Huan‐Tian Zhang   +15 more
wiley   +1 more source

Association of Aspirin Use with In-Hospital Mortality in Patients with Radiation-Associated Acute Pneumonitis: Insights from the National Inpatient Sample Database. [PDF]

Healthcare (Basel)
Sharma A, Shalini, Balasubramanian S, Yousaf H, Agrawal A, Vyas V.   +5 more
europepmc   +1 more source

A Fish MDA5 Integrates Canonical RIG‐I and MDA5 Ligand Recognition

Advanced Science, EarlyView.
These results show that the large yellow croaker lacks RIG‐I, yet its MDA5 senses both 5′ppp‐dsRNA and long dsRNA. A flexible RNA‐capping loop in the MDA5 C‐terminal domain enables two ligand‐binding modes. This dual recognition signals through MAVS–STING–TBK1/IRF3 and induces type I interferons, revealing unexpected plasticity in vertebrate antiviral ...
Wenxing Li, Yuan Feng, Huazhi Chen, Jiamei Liu, Álvaro Fernández Montero, Jiangtao Gao, Jingqun Ao, Xinhua Chen   +7 more
wiley   +1 more source