Results 111 to 120 of about 42,260 (251)

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

open access: yesAdvanced Science, EarlyView.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou   +8 more
wiley   +1 more source

Arbitrary 3D Organic Mixed Ionic‐Electronic Conductor Architectures via Self‐Fusion of PEDOT:PSS Microfibers

open access: yesAdvanced Science, EarlyView.
A general fabricating strategy for arbitrary 3D organic mixed ionic‐electronic conductor architectures is reported using PEDOT:PSS microfiber building blocks. A water‐assisted self‐fusion process is successfully developed in which adhesion can be modulated as reversible (PSS‐rich) or irreversible (PEDOT‐rich) self‐fusion depending on the post‐treatment
Youngseok Kim   +8 more
wiley   +1 more source

Protocol for a systematic review of the diagnostic and prognostic utility of tests currently available for the detection of aspirin resistance in patients with established cardiovascular or cerebrovascular disease [PDF]

open access: gold, 2013
Smriti Raichand   +8 more
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

open access: yesAdvanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu   +11 more
wiley   +1 more source

Aspirin resistance candidate genes and their association with the risk of fatal cardiovascular events

open access: yesТерапевтический архив, 2013
The review presents the current data available in the world literature on the most likely gene polymorphisms, such as cyclooxygenase, glycoproteins (GP) Ib/IIIa, GP Ibα, GP VI, adenosine diphosphate receptor P2Y1 and P2Y12 polymorphisms that may lead to ...
Iu I Grinshteĭn   +2 more
doaj  

Aspirin Resistance and Compliance with Therapy [PDF]

open access: bronze, 2010
Jesse Dawson   +6 more
openalex   +1 more source

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

open access: yesAdvanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

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