Results 51 to 60 of about 141,076 (306)

Tokyo Metropolitan Parks as urban forestry assemblagesreframing more-than-human commons in the city

open access: yesJournal of Asian Architecture and Building Engineering, 2022
This study explores urban forestry as a maintenance practice capable of enhancing more-than-human commons in the city. Focusing on the places associated with tree care, the methodology takes as a case study the Tokyo Metropolitan Parks, conducting ...
Diego Martín Sánchez   +2 more
doaj   +1 more source

Ambiguous Assemblage: Sublime Architectural Narratives, Urban Assemblage: The City as Architecture, Media, AI and Big Data

open access: yes, 2022
Hyperreal architectural assemblages are pervading our daily experience and progressively disrupting our spatial practices. Thought-provoking paradigms using VAM (virtual, augmented and mixed) realities profoundly transform our perception of space ...
Manfredini, Manfredo, Pretty, Annabel
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Translocation in a fragmented river provides demographic benefits for imperiled fishes

open access: yesEcosphere
Fragmentation isolates individuals and restricts access to valuable habitat with severe consequences for populations, such as reduced gene flow, disruption of recolonization dynamics, reduced resiliency to disturbance, and changes in aquatic community ...
Casey A. Pennock   +6 more
doaj   +1 more source

Advanced survey effort required to obtain bat assemblage data in temperate woodlands (Chiroptera) [PDF]

open access: yes, 2020
There is a lack of precise guidelines concerning the survey effort required for advanced bat surveys in temperate European woodlands, resulting in a lack of standardisation in survey methods.
Kaburu, Stefano SK   +4 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Fixing Non-market Subjects: Governing Land and Population in the Global South

open access: yesFoucault Studies, 2014
Expert knowledge about society and human nature is essential to governing human conduct.  It figures in the formulation of the liberal and neoliberal rationalities of government that Foucault analyzed in his later work.
Tania Murray Li
doaj   +1 more source

Ztělesnění feministické teorie [PDF]

open access: yesGender a Výzkum, 2016
This text traces the development and implications of strategies of remembering the body in feminist theory, after what could be termed the somaphobia of early second-wave scholarship that saw attention to bodily matters as a potential point of ambush by ...
Margrit Shildrick
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

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