Results 81 to 90 of about 424,084 (275)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Archive Report: Lithics from Cnoc an Fhoimheir, Lodge Farm, Kirkapol, Tiree [PDF]
, 2018 An analysis of the lithic assemblage from the excavations undertaken by Calluna Archaeology at Cnoc an Fhoimheir, Lodge Farm, Kirkapol ...
Wright, Dene
core
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
, 2022 Basierend auf der gescheiterten Rezeption des Brutalismus will ihn dieses Projekt in eine neue Position rücken. Vielerorts finden sich seine Gebäude als verlorene Aliens einer ursprünglich utopischen Ideologie wieder. In einer anthropozänen und kritischen Zeit für Umwelt und Ökologie ist es wichtig, diese Ruinen des Kapitalismus neu zu denken.
openaire +3 more sources
Plant remains from Middle Bronze Age round houses in north Cork [PDF]
, 2014 .pdf file with report describing analysis of archaeobotanical material from Ballynamona 2 and Mitchelstown 1 in north Cork ...
Johnston, Penny
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Evidence of exchange networks: the combs and other worked skeletal material [PDF]
, 2012 Significant contribution to the study of skeletal material in the Norse period using large internationally significant assemblage from Norse site in ...
Ashby, S., Batey, C.
core +1 more source
Neo-Hookean fiber composites undergoing finite out-of-plane shear deformations
, 2005 The response of a neo-Hookean fiber composite undergoing finite out-of-plane shear deformation is examined. To this end an explicit close form solution for the out-of-plane shear response of a cylindrical composite element is introduced. We find that the
deBotton +11 more
core +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source