Results 91 to 100 of about 182,080 (250)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
, 2022 Basierend auf der gescheiterten Rezeption des Brutalismus will ihn dieses Projekt in eine neue Position rücken. Vielerorts finden sich seine Gebäude als verlorene Aliens einer ursprünglich utopischen Ideologie wieder. In einer anthropozänen und kritischen Zeit für Umwelt und Ökologie ist es wichtig, diese Ruinen des Kapitalismus neu zu denken.
openaire +3 more sources
Electrochemical Sensor for Explosives Precursors’ Detection in Water
Challenges, 2017 Although all countries are intensifying their efforts against terrorism and increasing their mutual cooperation, terrorist bombing is still one of the greatest threats to society.
Cloé Desmet +5 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
B-DATA Big Data Assemblages: Techniques and Actors
, 2017 B-DATA aims to examine the emerging and evolving data assemblages producing open data, data infrastructure and big data. Ubiquitous and pervasive technology allows a massive production of New data (Big data, Big corpora, Open data, Linked data, etc ...
ARAGONA, BIAGIO
core
Rapid Biodiversity Assessment and Monitoring Method for Highly Diverse Benthic Communities: a Case Study of Mediterranean Coralligenous Outcrops [PDF]
, 2011 Increasing anthropogenic pressures urge enhanced knowledge and understanding of the current state of marine biodiversity. This baseline information is pivotal to explore present trends, detect future modifications and propose adequate management actions ...
Ballesteros i Sagarra, Enric +32 more
core +2 more sources
Brazilian Journal of BiologyHabitat fragmentation is well known to adversely affect species living in the remaining, relatively isolated, habitat patches, especially for those having small range size and low density.
CFD. Rocha +8 more
doaj +1 more source