Results 131 to 140 of about 15,680,037 (343)

Expert model of risk assessment for the selected components of smart city concept: From safe time to pandemics as COVID-19

, 2022
Beáta Gavurová, Мирослав Келемен, Volodymyr Polishchuk   +2 more
openalex   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Proof of concept for quantitative adverse outcome pathway modeling of chronic toxicity in repeated exposure

Scientific Reports
Adverse Outcome Pathway (AOP) is a useful tool to glean mode of action (MOE) of a chemical. However, in order to use it for the purpose of risk assessment, an AOP needs to be quantified using in vitro or in vivo data.
Shigeaki Ito, Sayak Mukherjee, Kazuo Erami, Shugo Muratani, Akina Mori, Sakuya Ichikawa, William White, Kei Yoshino, Dawn Fallacara   +8 more
doaj   +1 more source

Death to Kappa: birth of quantity disagreement and allocation disagreement for accuracy assessment

, 2011
Robert Gilmore Pontius, Marco Millones
openalex   +2 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

The Pregnancy Risk Assessment Monitoring System (PRAMS): Overview of Design and Methodology

, 2018
Holly B. Shulman, Denise V. D’Angelo, Leslie Harrison, Ruben Smith, Lee Warner   +4 more
openalex   +2 more sources

Pilot Study for the Dietary Assessment of Xenobiotics Derived from Food Processing in an Adult Spanish Sample [PDF]

, 2022
Aida Zapico, Sergio Ruiz-Saavedra, María Gómez‐Martín, Clara G. de los Reyes‐Gavilán, Sónia González   +4 more
openalex   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

A Method for Adjusting EQ-5D-3L Health State Utilities for Cross-Country Use: Application of a Novel US-to-UK Utility Mapping Approach

ClinicoEconomics and Outcomes Research
Abdul Jabbar Omar Alsaleh,1 Jerome Msihid,2 Elisheva Lew,3 Charlie Nicholls4 1Health Economics and Value Assessment, Sanofi, Milan, Italy; 2Health Economics and Value Assessment, Sanofi, Gentilly, France; 3Health Economics and Value Assessment, Sanofi ...
Omar Alsaleh AJ, Msihid J, Lew E, Nicholls C   +3 more
doaj