Results 221 to 230 of about 5,534,789 (298)

Malignant fungating wounds assessment in palliative care: a scoping review. [PDF]

Front Public Health
Nigrelli D, Gambalunga F, Anastasi G, Peghetti A, Durante S, Giusti M, Biagioli V, Quirini S, Iacorossi L, Latina R.   +9 more
europepmc   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Effect of educational training about CAM-ICU on nurses' knowledge, confidence, and practice to detect delirium among critically ill patients in intensive care unit. [PDF]

BMC Nurs
Hebeshy MI, Gaballah S, Elsayed ER.
europepmc   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Clinical Tools for Assessing One-Handed Skills in Children With Cerebral Palsy: An Umbrella Review. [PDF]

Occup Ther Int
Boroumand S, Pashmdarfard M, Hamedi D, Mehraban AH.   +3 more
europepmc   +1 more source

The assessment of physical fitness by correlation of vital capacity and certain measurements of the body, with tables, by Georges Dreyer ... in collaboration with George Fulford Hanson ...

, 1920
Georges Dreyer, G Hanson
openalex   +2 more sources

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Interchangeability of patient pain, fatigue and global scores in patients with spondyloarthritis - a registry-based simulation study. [PDF]

BMC Rheumatol
Georgiadis S, Di Giuseppe D, Scherer A, Hetland ML, Jones GT, Glintborg B, Loft AG, Wallman JK, Michelsen B, Kristianslund EK, Yazici A, Birlik M, Závada J, Nissen MJ, Ciurea A, Gudbjornsson B, Palsson O, Rotar Z, Tomšič M, Relas H, Huhtakangas J, Rodrigues AM, Santos MJ, Castrejon I, Díaz-González F, van de Sande M, Hellamand P, Ørnbjerg LM.   +27 more
europepmc   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Daily Diary Smartphone Assessment of Subjective Cognitive Concerns in Motoric Cognitive Risk Syndrome: A Pilot Study. [PDF]

Health Sci Rep
Nester CO, García de la Garza Á, Mogle JA, Wang C, Katz MJ, Ayers E, Lipton RB, Verghese J, Rabin LA.   +8 more
europepmc   +1 more source