Results 221 to 230 of about 9,331,066 (286)

Beyond Observable Behavior: A Narrative Review of Integrated Clinical, Biological, and Functional Assessment in Children With Autism Spectrum Disorder. [PDF]

Cureus
Sanabria F.
europepmc   +1 more source

Assessing the assessment

, 2010
Rami, Justin, Lorenzi, Francesca
openaire   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

A CT Lesion Foundation Model for Non-Invasive Assessment of Hepatocellular Carcinoma Aggressiveness and Prediction of Recurrence Risk. [PDF]

Adv Sci (Weinh)
Xia W, Shen Z, Li M, Lu J, Xia J, Cheng Y, Li W, Dong S, Deng L, Li R.   +9 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Design and evaluation of FEBS Education and Training Academy module - Integrating generative artificial intelligence into life-science education. [PDF]

FEBS Open Bio
Mlinarić Z, Özkaya AB.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Instruments and scales for assessment, screening, and psychoeducational diagnosis of children and adolescents with autism spectrum disorder: a scoping review. [PDF]

Rev Paul Pediatr
Oliveira KS, Britto DBOE, Fernandes GNA, Lemos SMA.   +3 more
europepmc   +1 more source