Results 141 to 150 of about 7,216,108 (304)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Assessment methodology for human-exoskeleton interactions: Kinetic analysis based on muscle activation. [PDF]

Front Neurorobot, 2022
Fanti V, Sanguineti V, Caldwell DG, Ortiz J, Di Natali C.   +4 more
europepmc   +1 more source

AMAP Assessment 2015: Black Carbon and Ozone as Arctic Climate Forcers [PDF]

, 2015
This assessment report presents the results of the 2015 AMAP Assessment of Black Carbon and Ozone as Arctic climate forcers.
Arctic Monitoring and Assessment Programme
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Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

A Cyber-Security Risk Assessment Methodology for Medical Imaging Devices: the Radiologists' Perspective. [PDF]

J Digit Imaging, 2022
Mahler T, Shalom E, Makori A, Elovici Y, Shahar Y.   +4 more
europepmc   +1 more source

What can e-assessment do for learning and teaching? Part 1 of a draft of current and emerging practice review by the e-Assessment Association expert panel

, 2012
This paper serves as part of a review by the e-Assessment Association (eAA) in its desire to make a positive contribution to the assessment arena.
Beevers, Cliff, al., et
core  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Capacity building in European health information systems: the InfAct peer assessment methodology. [PDF]

Eur J Public Health, 2022
Bogaert P, Verschuuren M, Van Oyen H, van Oers H.   +3 more
europepmc   +1 more source

Wellbeing assessment resource

, 2017
The recently released Wellbeing Practice Guide, developed by the Victorian Department of Education (DET) and the Victorian Curriculum and Assessment Authority (VCAA) is designed to inform a greater understanding of wellbeing and its place as both a ...
Victorian Curriculum and Assessment Authority
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