Results 161 to 170 of about 7,216,108 (304)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Reliability and Quality of Complex Systems

Надежность и качество сложных систем
Background. The ongoing study is aimed at developing methods and information technologies for monitoring and assessing the resilience of critical entities and infrastructures to improve the efficiency of situational management of these complex dynamic ...
A.V. Masloboev, V.N. Tsygichko
doaj   +1 more source

A Scoping Review of Epidemiological Studies on Intake of Sugars in Geographically Dispersed Asian Countries: Comparison of Dietary Assessment Methodology. [PDF]

Adv Nutr, 2022
Fujiwara A, Omura Y, Oono F, Sugimoto M, Sugimoto M, Sasaki S, Takimoto H.   +6 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Strategic Directions for Improving the Quality of Life of the Population of the Arctic Territories of the Republic of Karelia

Управленческое консультирование
The article presents the results of a comprehensive study of strategic directions for improving the quality of life of the population in the Arctic territories of the Republic of Karelia. The relevance of the research is determined by the need to develop
A. A. Kozyrev, A. A. Zaretsky
doaj  

Estimating risk factor attributable burden - challenges and potential solutions when using the comparative risk assessment methodology. [PDF]

Arch Public Health, 2022
Plass D, Hilderink H, Lehtomäki H, Øverland S, Eikemo TA, Lai T, Gorasso V, Devleesschauwer B.   +7 more
europepmc   +1 more source

A history of three e-assessment programmes in England

, 2012
This article considers the use of e-assessment in England in three major education policy initiatives: the key stage 3 Information & Communication Technology (ICT) test, Basic & Key Skills (BKS) testing, and Functional Skills.
Sowerbutts, Paul, Boyle, Andrew, Sceeny, Paul, May, Tom   +3 more
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Release Assessment Methodology for Safe, Sustainable, and Recyclable By-Design Practices for Plastics: The Epoxy-Resin Composite Case Study. [PDF]

Nanomaterials (Basel)
Cazzagon V, Schmidt PM, Pellegrin B, Fontaine H, Tissier D, Huegun A, Berner V, Höhne CC, Artous S, Vázquez-Campos S, Delpivo C.   +10 more
europepmc   +1 more source

A bespoke health risk assessment methodology for the radiation protection of astronauts. [PDF]

Radiat Environ Biophys, 2021
Walsh L, Hafner L, Straube U, Ulanowski A, Fogtman A, Durante M, Weerts G, Schneider U.   +7 more
europepmc   +1 more source