Results 121 to 130 of about 333,852 (304)

Longitudinal Course and Baseline Predictors of Trajectories of Clinician-assessed Adherence to Immunosuppressant Medication in Patients after Kidney Transplantation: A KTx360° Substudy

Transplantation Direct
Background. Optimal and maintained adherence to immunosuppressive medication is essential to kidney graft success. Methods. We analyzed the longitudinal course of immunosuppressant adherence as measured with the Basel Assessment of Adherence to ...
Martina de Zwaan, MD, Mariel Nöhre, MD, Felix Klewitz, Dipl-Psych, PhD, Maximilian Bauer-Hohmann, Dipl-Psych, Charlotte Kuczyk, MSc, Yesim Erim, MD, Lena Schiffer, MD, Deborah Meier, PhD, Julia K. Wolff, Dipl-Psych, PhD, Uwe Tegtbur, MD, Lars Pape, MD, Mario Schiffer, MD   +11 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Assessment of Medication Adherence Using Pharmacy Data Before and After Percutaneous Coronary Intervention. [PDF]

Patient Prefer Adherence, 2023
Abera SM, O'Donnell C, Salahuddin T, Prabhu K, Simons CE, Ho PM, Waldo SW, Doll JA.   +7 more
europepmc   +1 more source

Adherence to antiretroviral therapy in patients enrolled in a comprehensive care program in Cambodia: a 24-month follow-up assessment [PDF]

, 2008
BACKGROUND: The long-term maintenance of antiretroviral therapy (ART) remains an important issue, especially in limited-resource settings where additional barriers exist.
Carrieri, Patrizia, Delfraissy, Jean-François, Ferradini, Laurent, Laureillard, Didier, Ngeth, Chanchhaya, Prak, Narom, Protopopescu, Camelia, Quillet, Catherine, Sopha, Pal, Spire, Bruno   +9 more
core   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Evaluating the Effectiveness of Mobile Apps on Medication Adherence for Chronic Conditions: Systematic Review and Meta-Analysis

Journal of Medical Internet Research
BackgroundMedication adherence is crucial for managing chronic conditions. Mobile apps may have the potential, through a wide variety of features, to support and improve medication adherence. ObjectiveThe purpose of this systematic review was
Vaidehee Lanke, Kevin Trimm, Bettina Habib, Robyn Tamblyn   +3 more
doaj   +1 more source

Current Knowledge and Attitudes Concerning Cost-Effectiveness in Glaucoma Pharmacotherapy: A Glaucoma Specialists Focus Group Study. [PDF]

, 2020
Background:Rising healthcare costs motivate continued cost-reduction efforts. To help lower costs associated with open-angle glaucoma (OAG), a prevalent, progressive disease with substantial direct and indirect costs, clinicians need to understand the ...
Cioffi, George A, Feldman, Robert M, Feldman, Robert M, Liebmann, Jeffrey M, Weinreb, Robert N   +4 more
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Assessment of Medication Adherence and Pharmacist Intervention Are Important for the Care of Patients with Inflammatory Bowel Disease. [PDF]

Gut Liver, 2022
Kim ES, Kang B.
europepmc   +1 more source