Results 171 to 180 of about 8,067,926 (304)

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Assessment tools for frailty in elderly adults: A scoping review. [PDF]

Medicine (Baltimore)
Ye D, Zhao J, Cui S, Chen L.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Assessing the quality of care in low- and middle-income countries: a rapid review of the landscape of assessment tools. [PDF]

BMJ Glob Health
Togbenon NDL, Cooper S, Vigan AA, Lokossou SE, Danhoundo R, Agoligan Tometin NJE, Agossou MCU, Dossou RSL, Dossou JP, Criel B, Bello K.   +10 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Assessing the Utility of Automated and Pen-And-Paper Cognitive Assessment Tools for Underrepresented Groups in the UK. [PDF]

Int J Geriatr Psychiatry
Illingworth CH, Pahar M, Braun D, Sproson L, Khan H, Mirheidari B, O'Malley R, Abdi S, Jama M, Yussuf I, Wang C, Lee S, Ng S, Ali N, Basharat T, Rauf MA, Nadeem A, Christensen H, Blackburn DJ.   +18 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Cultural adaptation process of six stigma assessment scales among Kannada speaking population in South India – CORRIGENDUM

Cambridge Prisms: Global Mental Health
Harshitha H Annajigowda, Gurucharan Bhaskar Mendon, Anish V. Cherian, Syed Shabab Wahid, Brandon A. Kohrt, Nicolas Rüsch, Sara Evans-Lacko, Elaine Brohan, Claire Henderson, Graham Thornicroft, Santosh Loganathan   +10 more
doaj   +1 more source

The application value of frailty assessment tools in the perioperative period: A narrative review. [PDF]

J Anesth Transl Med
Shen H, Ju M, Wu X, Shi S, Sun J, Tian M.   +5 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source