Results 61 to 70 of about 56,791 (294)

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

open access: yesAdvanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang   +21 more
wiley   +1 more source

Reversal of the Pension Reform in Poland

open access: yesSocialiniai Tyrimai, 2016
In the past, the Polish pension system was based on a pay-as-you-go rule. On 1 January 1999 Poland introduced a major pension reform in order to improve sustainability of the pension system. The new system consisted of three independent pillars.
Sebastian Jakubowski
doaj   +1 more source

TALF: Jump-starting the securitization markets [PDF]

open access: yes
In the financial crisis that began in August 2007, securitization activity virtually dried up. When the housing bubble burst, the value of the collateral backing much of the asset-backed securities (ABS) declined sharply, and so did the value of the ...
Kenneth J. Robinson
core  

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

open access: yesAdvanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang   +4 more
wiley   +1 more source

Corporate bonds, asset-backed securities and deferred checks in Argentina [PDF]

open access: yes
We describe the evolution of three types of corporate securities in Argentina, namely, corporate bonds, asset-backed securities and deferred checks. Corporate bonds (obligaciones negociables) were legally authorized in 1988, and after a tax reform in ...
Alejandro Bedoya   +4 more
core  

Diversification first: Why the euro area does not need an artificial safe asset. CEPS Commentary, 25 May 2018 [PDF]

open access: yes, 2018
The European Commission has now tabled ‘enabling’ legislation for the creation of ‘SBBS’, sovereign bond-backed securities. The official purpose is to allow financial markets to create a ‘safe asset’, which should be used by banks instead of government ...
Gros, Daniel.
core  

AI‐Assisted Self‐Powered Wearable Dual‐Mode Sensor With TENG and Stretchable Optical Fiber for Neurological Disorder Diagnostics

open access: yesAdvanced Science, EarlyView.
This manuscript presents the WDMS platform, an AI‐assisted, self‐powered wearable dual‐mode sensor for tele‐neurology. It integrates a contact–separation TENG insole with stretchable polyurethane optical‐fiber strain sensors to synchronously track plantar pressure and lower‐limb muscle deformation.
Tianliang Li   +12 more
wiley   +1 more source

A Balancing Act: Making the Canadian Secured Credit Facility Work [PDF]

open access: yes
The January 2009 federal budget proposed funding a “Canadian Secured Credit Facility” as part of an economic action plan. This Facility will allocate up to $12 billion to purchases of term asset-backed securities (ABS) for loans and leases on vehicles ...
Alexandre Laurin
core  

Shared scepticism, different motives: Franco-German perceptions of a common European safe asset. Bertelsmann Stiftung 26 October 2018 [PDF]

open access: yes, 2018
A common European safe asset is a highly contentious proposal within the Euro area reform agenda. Various safe asset proposals have been put forward since the onset of the Euro crisis ranging from Eurobonds to European Safe Bonds (ESBies), also known as ...
Best, Kris
core  

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo   +9 more
wiley   +1 more source

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