Results 91 to 100 of about 1,037,455 (301)

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

open access: yesAdvanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun   +14 more
wiley   +1 more source

Does Digital Asset Allocation Improve Corporate ESG Performance? Evidence from China

open access: yesMathematics
Against the backdrop of the deep integration of the “Dual Carbon” goals and the digital economy, whether digital asset allocation can improve corporate Environmental, Social, and Governance (ESG) performance has become an important topic of academic ...
Keyue Chen   +3 more
doaj   +1 more source

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD‐L1 Transcription

open access: yesAdvanced Science, EarlyView.
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue   +6 more
wiley   +1 more source

The Impact of Short-Sale Constraints on Asset Allocation Strategies via the Backward Markov Chain Approximation Method [PDF]

open access: yes
This paper considers an asset allocation strategy over a finite period under investment uncertainty and short-sale constraints as a continuous time stochastic control problem.
Chih-Ying Hsiao, Carl Chiarella
core  

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming   +9 more
wiley   +1 more source

Risk, Mispricing, and Asset Allocation: Conditioning on Dividend Yield [PDF]

open access: yes
In the asset pricing literature, time-variation in market expected excess return captured by financial ratios like dividend yield is typically viewed as a reflection of either changing risk, related to the business cycle, or irrational mispricing ...
Jay Shanken, Ane Tamayo
core  

Equity risk versus retirement adequacy: asset allocation solutions for KiwiSaver

open access: yes, 2019
New Zealand's KiwiSaver superannuation system operates with a conservatively low asset allocation towards equity investments. Evidence suggests ‘conservative’ portfolios are riskier than portfolios holding more growth assets when considering shortfall ...
Bianchi, Robert J   +5 more
core   +1 more source

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