Results 131 to 140 of about 1,081,213 (302)
Advanced Science, EarlyView.A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang +10 more
wiley +1 more source
FinTechThis research paper explores the complicated connection between uncertainty and the Markowitz asset allocation framework, specifically investigating how mistakes in estimating parameters significantly impact the performance of strategies during out-of ...
Vijaya Krishna Kanaparthi
doaj +1 more source
Dynamic asset allocation with asset-specific regime forecasts
Annals of Operations ResearchThis article introduces a novel hybrid regime identification-forecasting framework designed to enhance multi-asset portfolio construction by integrating asset-specific regime forecasts. Unlike traditional approaches that focus on broad economic regimes affecting the entire asset universe, our framework leverages both unsupervised and supervised ...
Yizhan Shu, Chenyu Yu, John M. Mulvey
openaire +2 more sources
Asset allocation theory and practice in Australian investment management
, 2016 Asset allocation is the decision on how much of the investment portfolio to place in each of the broad asset classes (e.g. cash, fixed interest securities, property, equities).
Santacruz, Lujer
core
Advanced Science, EarlyView.A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun +9 more
wiley +1 more source
Portfolio Construction Under Behavioral Distortions and Narrow Framing: A Machine Learning Approach
MathematicsThis paper develops a portfolio construction methodology integrating behavioral finance principles with machine learning to model how cognitive biases systematically alter asset allocation decisions.
Georgios Tsomidis
doaj +1 more source
Advanced Science, EarlyView.DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang +8 more
wiley +1 more source
Traditional Asset Allocation Securities
, 2017 Asset allocation models have evolved in complexity with the development of modern portfolio theory, but they continue to operate under the assumption of investor rationality and other assumptions that do not hold in the real world.
Christopher Milliken +2 more
core +1 more source
Advanced Science, EarlyView.After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi +16 more
wiley +1 more source