Results 121 to 130 of about 1,037,455 (301)

International asset allocation under regime switching, skew and kurtosis preferences [PDF]

This paper proposes a new tractable approach to solving asset allocation problems in situations with a large number of risky assets which pose problems for standard approaches.
Massimo Guidolin, Allan Timmerman
core  

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

The Impact of Property Tax Expectations on Household Asset Allocation

Buildings
Rational asset allocation is central to household wealth accumulation. This paper employs data derived from the 2019 China Household Finance Survey to methodically examine the influence of property tax expectations on the asset allocation decisions of ...
Xinzhe Xu, Jun Wang, Zhou Li
doaj   +1 more source

Pension funds. asset allocation and participant age: a test of the life-cycle model [PDF]

This paper examines the impact of participants. age distribution on the asset allocation of Dutch pension funds, using a unique data set of pension fund investment plans for 2007.
Dirk W.G.A. Broeders, Eduard Ponds, Jacob A. Bikker, David Hollanders   +3 more
core  

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

Navigating Uncertainty: Enhancing Markowitz Asset Allocation Strategies through Out-of-Sample Analysis

FinTech
This research paper explores the complicated connection between uncertainty and the Markowitz asset allocation framework, specifically investigating how mistakes in estimating parameters significantly impact the performance of strategies during out-of ...
Vijaya Krishna Kanaparthi
doaj   +1 more source

Dynamic asset allocation with asset-specific regime forecasts

Annals of Operations Research
This article introduces a novel hybrid regime identification-forecasting framework designed to enhance multi-asset portfolio construction by integrating asset-specific regime forecasts. Unlike traditional approaches that focus on broad economic regimes affecting the entire asset universe, our framework leverages both unsupervised and supervised ...
Yizhan Shu, Chenyu Yu, John M. Mulvey
openaire   +2 more sources

Il processo di asset allocation

, 1995
Il capitolo descrive le fasi del processo di asset ...
GHIRINGHELLI, PAOLO
core  

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Portfolio Construction Under Behavioral Distortions and Narrow Framing: A Machine Learning Approach

Mathematics
This paper develops a portfolio construction methodology integrating behavioral finance principles with machine learning to model how cognitive biases systematically alter asset allocation decisions.
Georgios Tsomidis
doaj   +1 more source