Results 301 to 310 of about 8,885,351 (374)

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

A machine learning approach to risk based asset allocation in portfolio optimization. [PDF]

Sci Rep
Agal S, Raulji K, Odedra ND.
europepmc   +1 more source

Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

Advanced Science, EarlyView.
Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin, Yueying Lin, Dmitry Y. Guschin, Hsiang‐Ying Chen, John James, Jie Yan, Pascal Silberzan, Alexis M. Gautreau   +7 more
wiley   +1 more source

Integrating CAD, BIM, immersive technology, and 3D Gaussian Splatting for construction model coordination with ISO 19650. [PDF]

Sci Rep
Liao X, Liu Y, Huang Y, Luo Y, Zhou Z, Chong HY.   +5 more
europepmc   +1 more source

Evaluation of Management of the UAPF Pension Assets Based on the Method of Multidimensional Clustering

, 2017
Aigul Abitzhanovna Zhantayeva, Aizhan Sarsenovna Assilova, Aigul Malibekovna Atchabarova, D. B. Muratova, G. Amalbekova   +4 more
openalex   +1 more source

Long‐Term Effects of Xenotransplantation of Human Enteric Glia in an Immunocompetent Rat Model of Acute Brain Injury

Advanced Science, EarlyView.
Acute brain injuries are characterized by extensive tissue damage, resulting in debilitating deficits in patients. Despite considerable progress, cell‐based approaches have yet to identify an ideal candidate. This long‐term study explores the use of an untested cell source – human enteric glia – and a non‐invasive administration route – intranasal ...
Nina Colitti, Edwige Rice, Franck Desmoulin, Maylis Combeau, Mélissa Parny, Lorenne Robert, Etienne Buscail, Barbara Bournet, Nathalie Vergnolle, Isabelle Raymond‐Letron, Isabelle Loubinoux, Carla Cirillo   +11 more
wiley   +1 more source

Revisiting the excess volatility puzzle through the lens of the Chiarella model. [PDF]

PLoS One
Kurth JG, Majewski AA, Bouchaud JP.
europepmc   +1 more source

An Industrial Application of a Large Language Model to Enhancing Asset Integrity and Process Safety Management

Benard Ongwae, Ubong Ita Ekanem
openalex   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Design and validation of a flexible framework for developing generic digital twins for Industry 4.0. [PDF]

Sci Rep
Pribiš R, Drahoš P, Kozák Š, Beňo L, Kučera E, Haffner O, Pajpach M.   +6 more
europepmc   +1 more source