Results 41 to 50 of about 45,773 (257)

Emerging Reliability Challenges of Spillway Discharging Systems in Aging Hydroelectric Dams

open access: yesCivilEng
Factors such as asset aging, climate change affecting hydrological events, and the growing demand in electricity are placing huge pressure on hydroelectric infrastructure—in particular, hydroelectric dams, whose most important and critical component is ...
Peter Ghoche   +3 more
doaj   +1 more source

Impact of expenses on total return of actively managed equity funds

open access: yesИнтеллект. Инновации. Инвестиции, 2019
Investment funds play a leading role as a main instrument savings in economical systems of the developed countries. This appears in the fact that share of investment funds exposing to stocks and bonds is considerable in household savings; net asset value
A.O. Valukhov
doaj   +1 more source

False Financial Statement Identification Based on Fuzzy C-Means Algorithm

open access: yesComplexity, 2021
Financial accountants falsify financial statements by means of financial techniques such as financial practices and financial standards, and when compared with conventional financial data, it is found that the falsified financial data often lack ...
Jixiao Li
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Universal pattern in fermion mass ratios and implications for flavor models

open access: yesEuropean Physical Journal C: Particles and Fields
We show that a single analytic expression using only the labels that distinguish Standard Model mass eigenstates—the ordering index $$d\in \{1,2,3\}$$ d ∈ { 1 , 2 , 3 } and electric charge $$q$$ q —fits all fermion mass ratios with high precision and ...
Samir Varma
doaj   +1 more source

Raising the bar on the foreign portfolio to 25 per cent: Strategic implications for South African investors

open access: yesSouth African Journal of Economic and Management Sciences, 2015
Regulation 28 of the Pension Funds Act now permits an increased allocation of 25 per cent to foreign investments. The regulation previously only permitted a 20 per cent allocation.
David John Bradfield, Brian Munro
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

PHENOMENOLOGY OF THE POWER – GENESIS OF FORMS OF MANIFESTATION OF THE GLOBAL SYSTEM CONTRADICTION 'CREDITORS – DEBTORS'

open access: yesВестник Российского экономического университета имени Г. В. Плеханова, 2017
In article on the basis of the new concept of design and functioning of social and economic mechanisms developed by authors the system relationships of cause and effect causing variety of forms of life of a global system contradiction ′creditors reveal ...
Vyacheslav I. Karpunin   +1 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

open access: yesFEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti   +5 more
wiley   +1 more source

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