Results 91 to 100 of about 167,956,997 (283)

Flower Pollination Algorithm (FPA) to Solve Quadratic Assignment Problem (QAP)

open access: yesContemporary Mathematics and Applications (ConMathA), 2019
The purpose of this paper is to solve Quadratic Assignment Problem using Flower Pollination Algorithm. Quadratic Assignment Problem discuss about assignment of facilities to locations in order to minimize the total assignment costs where each facility ...
Derby Prayogo Samdean   +2 more
doaj   +1 more source

Distributed greedy algorithm for multi-agent task assignment problem with submodular utility functions

open access: yesat - Automatisierungstechnik, 2019
We consider a multi-agent task assignment problem where a group of agents need to select tasks from their admissible task sets. The utility of an assignment profile is measured by the sum of individual task utilities, which is a submodular function of ...
Guannan Qu, Dave Brown, Na Li
semanticscholar   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

A numerically reliable approach to robust pole assignment for descriptor systems [PDF]

open access: yes, 2003
We propose a general, numerically reliable computational approach to solve the pole and eigenstructure assignment problem for descriptor systems. In the multi-input case, the proposed approach addresses the intrinsic non-uniqueness of the pole assignment
A. Varga, Varga, Andras
core  

Adolescent Substance Use in the Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder (ADHD) (MTA) as a Function of Childhood ADHD, Random Assignment to Childhood Treatments, and Subsequent Medication

open access: yesJournal of the American Academy of Child and Adolescent Psychiatry, 2013
Objectives To determine long-term effects on substance use and substance use disorder (SUD), up to 8 years after childhood enrollment, of the randomly assigned 14-month treatments in the multisite Multimodal Treatment Study of Children with Attention ...
B. Molina   +19 more
semanticscholar   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Deep Fuzzy Clustering Network With Matrix Norm Regularization

open access: yesIEEE Access
Recently, deep clustering networks, which able to learn latent embedding and clustering assignment simultaneously, attract lots of attention. Among the deep clustering networks, the suitable regularization term is not only beneficial to training of ...
Feiyu Chen, Yan Li, Wei Wang
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

A geometric chracterization of the nucleolus of the assignment game [PDF]

open access: yes
core, assignment games, nucleolus, cooperative games ...
Francesc Llerena   +2 more
core  

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