Results 71 to 80 of about 167,956,997 (283)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

A General Statistical Physics Framework for Assignment Problems

open access: yesAlgorithms
Linear assignment problems hold a pivotal role in combinatorial optimization, offering a broad spectrum of applications within the field of data sciences.
Patrice Koehl, Henri Orland
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

A Random Traffic Assignment Model for Networks Based on Discrete Dynamic Bayesian Algorithms

open access: yesDiscrete Dynamics in Nature and Society, 2022
In this paper, a stochastic traffic assignment model for networks is proposed for the study of discrete dynamic Bayesian algorithms. In this paper, we study a feasible method and theoretical system for implementing traffic engineering in networks based ...
Wei Zhou
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Combinatorial assignment algorithm goals

open access: yesИзвестия высших учебных заведений. Поволжский регион:Технические науки
Background. Combinatorial algorithms for assigning targets (assignments) are used in the allocation of means of destruction (resources). The main advantage of combinatorial algorithms for local search for optimal target assignment is low asymptotic ...
A.V. Danilov, P.P. Makarychev
doaj   +1 more source

The Comparison of Single Debris Flow Risk Assessment Models in China

open access: yesShuitu baochi yanjiu, 2011
Since 1980,researchers of China have begun to study the risk of landslides and debris flow hazard.Single debris flow hazard assessment model has become function assignment from grading;and the basic principles and techniques have been initially formed ...
ZHANG Huai-zhen1   +3 more
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Energy conservation practices participant manual: For public housing residents and renters

open access: yes, 1988
This training manual focuses on actions which residents can take to improve energy conservation in their homes ...
The Assignment Group
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

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