Analyzing the Feasibility of Prairie Dog Hunting in the Northern Texas Panhandle [PDF]
Prairie dogs are burrowing rodents located throughout the United States. The black-tailed prairie dog is a common species that primarily inhabits the Great Plains region, with a large population in Texas.
Mayfield, Gid, Jones, DeDe
core
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Dog bite histories and response to incidents in canine rabies-enzootic KwaZulu-Natal, South Africa.
PLoS Neglected Tropical Diseases, 2013 The objective of this paper is to report evaluated observations from survey records captured through a cross-sectional observational study regarding canine populations and dog owners in rabies enzootic KwaZulu-Natal province, South Africa. Our aim was to
Melinda Hergert, Louis H Nel
doaj +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Supporting Clients Through Loss: Exploring Best Practices of Accredited Assistance Dog Organizations
DSW Capstone Report"Introduction/Background: This study describes the practices in place at United States- based assistance dog organizations accredited by Assistance Dogs International (ADI) (N=21) to assist and support clients who have experienced the ...
DeSantis, Dena
core +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
PTSD assistance dogs: concerns for animal well-being, rights, and justice
Frontiers in Veterinary SciencePTSD assistance dogs are service dogs trained to assist individuals living with PTSD. A growing body of research links the use of PTSD assistance dogs with substantial benefits for their human partners, including significant reductions in PTSD symptoms ...
Laura Kiiroja +2 more
doaj +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Australian parents' experiences of owning an autism assistance dog. [PDF]
Health Soc Care Community, 2022 Appleby R +3 more
europepmc +1 more source