Results 71 to 80 of about 1,793,621 (294)

Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping [PDF]

open access: yes, 2011
The extraordinary phenotypic diversity of dog breeds has been sculpted by a unique population history accompanied by selection for novel and desirable traits.
Derrien, Thomas   +253 more
core   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Craniocervical junction abnormalities with atlantoaxial subluxation caused by ventral subluxation of C2 in a dog [PDF]

open access: yesOpen Veterinary Journal, 2017
Craniocervical junction abnormalities with atlantoaxial subluxation caused by ventral subluxation of C2 were diagnosed in a 6-month-old female Pomeranian with tetraplegia as a clinical sign.
Harumichi Itoh   +10 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Assistance dog week

open access: yes, 2016
This proclamation from Governor Nikki Haley proclaims August 7-13, 2016 as Assistance Dog ...
South Carolina Office of the Governor   +1 more
core   +1 more source

APPLICATION OF ANIMAL ASSISTANCE AT THE UNIVERSITY OF DEBRECEN FACULTY OF EDUCATION FOR CHILDREN AND SPECIAL EDUCATIONAL NEEDS

open access: yesKülönleges Bánásmód
Animal assistance used among university students is not unknown, numerous foreign examples prove its valid existence. The application aimed at university students appeared in the United States of America, but nowadays it is used in many countries around ...
Antal Lovas Kiss
doaj   +1 more source

Longitudinal evidence for the emergence of multiple intelligences in assistance dog puppies

open access: yesbioRxiv
Cognitive test batteries suggest that adult dogs have different types of cognitive abilities that vary independently. In the current study, we tested puppies repeatedly over a crucial period of development to explore the timing and rate at which these ...
Hannah Salomons   +11 more
semanticscholar   +1 more source

Towards an Augmented Assistance Dog

open access: yes, 2015
Despite the recent progresses in robotics, autonomous robots still have too many limitations to reliably help people with disabilities. On the other hand, animals, and especially dogs, have already demonstrated great skills in assisting people in many daily situations. However, dogs also have their own set of limitations. For example, they need to rest
Yves Rybarczyk   +4 more
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

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