Results 81 to 90 of about 1,793,621 (294)

Beyond puppy selection—considering the role of puppy raisers in bringing out the best in assistance dog puppies

open access: yes, 2020
Problem behaviours are the most common reason to reject young dogs from entering advanced training and obtaining certification for work as an assistance dog.
D. Mai   +3 more
semanticscholar   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The effects of assistance dogs on psychosocial health and wellbeing: A systematic literature review.

open access: yesPLoS ONE, 2020
Beyond the functional tasks that assistance dogs are trained for, there is growing literature describing their benefits on the psychosocial health and wellbeing of their handlers.
Kerri E Rodriguez   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Maximising the Potential Benefit of Living with Companion Dogs for Autistic Children and Their Families: A Mixed-Methods Survey of the Impact of a Novel ‘Family Dog Service’

open access: yesAnimals
Background: Assistance dogs can support children with autism by improving emotional regulation and social functioning, but access is limited. The Family Dog Service was developed to help families of autistic children gain similar benefits through ...
Emily Shoesmith   +6 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

The effects of assistance dogs on social acknowledgements and engagement of people with visible disabilities – A case study

open access: yesHuman-Animal Interactions
Stigmatization of people with visible disabilities is a well-recognized concept, as is the knowledge that Assistance Dogs (ADs) may serve as social lubricants. This case study explored the interplay of these two concepts in the everyday life of a person (
Colin Pugh, Carmel Nottle, Janette Young
doaj   +1 more source

The impact of service and hearing dogs on health-related quality of life and activity level: a Swedish longitudinal intervention study

open access: yesBMC Health Services Research, 2018
Background Individuals with severe disability often require personal assistance and help from informal caregivers, in addition to conventional health care.
Martina Lundqvist   +3 more
doaj   +1 more source

Interacting with assistance dogs and their owners

open access: yes, 2014
A GUIDE dog and its owner have been helping veterinary nursing students at Edinburgh Napier University to gain experience of the practicalities of working with assistance dogs and their owners, both in practice and in everyday ...
Fraser, Mary
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

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