Results 111 to 120 of about 1,140,834 (267)

Cognitive assistants [PDF]

International Journal of Human-Computer Studies, 2018
Ângelo Costa, Paulo Novais, Vicente Julián, Grzegorz J. Nalepa   +3 more
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Factors Affecting Pregnancy Outcomes in Patients Undergoing in vitro Fertilization/Intracytoplasmic Sperm Injection-Embryo Transfer (IVF/ICSI-ET) After Hysteroscopic Adhesiolysis: A Clinical Analysis

International Journal of Women's Health
Xiaoying Jin,1– 3 Yangyang Wang,1– 3 Xiufen Wang,1– 3 Chao Li,1– 3 Xia Hong,1– 3 Fang Hong,1– 3 Songying Zhang1– 31Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine ...
Jin X, Wang Y, Wang X, Li C, Hong X, Hong F, Zhang S   +6 more
doaj  

Comparison of Manual Versus Robot-Assisted Piston Prosthesis Placement and Crimping in a 3D-Printed Temporal Bone Model. [PDF]

Laryngoscope Investig Otolaryngol
Daoudi H, Coban A, Torres R, Ekici R, Ferrary E, Nguyen Y, Sheppard SC.   +6 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Development and Evaluation of an Ergonomically Optimized Scope-Holder for Flexible Endoscopy (With Video). [PDF]

Dig Endosc
Nagano S, Momose K, Ishii Y, Yamaguchi S, Nakai S, Hagi T, Yamashita K, Saito T, Tanaka K, Makino T, Takahashi T, Kurokawa Y, Eguchi H, Doki Y, Nakajima K.   +14 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autonomous robotic execution of nonlinear toolpaths for geometry-matched osteotomy in tooth autotransplantation: an in vitro study. [PDF]

Int J Oral Sci
Liu C, Chen G, Zhou L, Qiu J, Li D, Liu Y, Li Z, Bai S, Zhao Y.   +8 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source