Results 211 to 220 of about 2,641,039 (362)

Reservoir‐Type Subcutaneous Implantable Devices Containing Porous Rate Controlling Membranes for Sustained Delivery of Risperidone

Advanced Healthcare Materials, EarlyView.
This study presents a novel implantable drug delivery systemwith a biodegradable poly(caprolactone) membrane and compressed drug core forsustained release. These implantable devices deliver risperidone in vitro for 170 days and in vivo for 49 days in rats, showing promise for chronic conditions like schizophrenia.
Linlin Li, Andi Dian Permana, Juan Domínguez‐Robles, Muh Nur Amir, Habibie Habibie, Qonita Kurnia Anjani, Li Zhao, Natalia Moreno‐Castellanos, Ryan F Donnelly, Eneko Larrañeta   +9 more
wiley   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Using a Deep Learning-Based Decision Support System to Predict Emergent Large Vessel Occlusion Using Non-Contrast Computed Tomography. [PDF]

J Clin Med
Lee SJ, Kim D, Choi DH, Lim YS, Park G, Jung S, Song S, Hong JM, Shin DH, Kim MJ, Lee JS.   +10 more
europepmc   +1 more source

Transluminal Stent-assisted Angioplasty of the Intracranial Vertebrobasilar System for Medically Refractory, Posterior Circulation Ischemia: Early Results

, 2001
Peter A. Rasmussen
openalex   +1 more source

Use of miniaturized extracorporeal circulation for implanting left ventricular assist devices in high-risk end-stage heart failure patients [PDF]

, 2013
Polychronis Antonitsis, Helena Argiriadou, Paschalis Tossios, Apostolos Deliopoulos, S Westaby, Kyriakos Anastasiadis   +5 more
openalex   +1 more source

It is not just assisted circulation, hypothermic arrest, or clamp and sew.

Journal of Thoracic and Cardiovascular Surgery, 2010
C. Acher
semanticscholar   +1 more source

Covalent Binding of Dexamethasone to Polyimide Improves Biocompatibility of Neural Implantable Devices

Advanced Healthcare Materials, EarlyView.
The covalent binding of dexamethasone to the surface of polyimide represents the electrically inert part of implantable intraneural devices. This ensures a sustained release of the drug for 9 weeks. In vitro and in vivo tests confirm the reduction of the foreign body reactions and the improved biocompatibility of dexamethasone functionalized polyimide.
Giulia Turrin, Jose Crugeiras, Chiara Bisquoli, Davide Barboni, Martina Catani, Bruno Rodríguez‐Meana, Rita Boaretto, Michele Albicini, Stefano Caramori, Claudio Trapella, Thomas Stieglitz, Yara Baslan, Hanna Karlsson‐Fernberg, Fernanda L. Narvaez‐Chicaiza, Edoardo Marchini, Alberto Cavazzini, Ruben López‐Vales, Maria Asplund, Xavier Navarro, Stefano Carli   +19 more
wiley   +1 more source

Short- and mid-term outcomes of surgical repair of acute type A aortic dissection and concomitant coronary artery bypass grafting or extracorporeal membrane oxygenation support. [PDF]

Interdiscip Cardiovasc Thorac Surg
Zhang D, Zhu GJ, Gao MJ, Wei XY, Yan Z, Li B, Chen XP, Wang XL, Shu YS.   +8 more
europepmc   +1 more source

Postcardiotomy assisted circulation with roller pump-early and late results

, 2003
A. Nezic, Aleksandar Knežević, Milan Ćirković, Predrag Milojević, Miroslav Jakovljevic, Siniša Jagodić   +5 more
openalex   +2 more sources

Enhancing the Pharmacokinetics of Aptamers: Targeting AXL In Vivo Using a Bottlebrush Polymer‐Conjugated Aptamer

Advanced Healthcare Materials, EarlyView.
A phosphodiester‐backboned bottlebrush polymer (pacDNA) engineered for aptamer delivery is presented. This design enhances aptamer stability, plasma pharmacokinetics, and target engagement in vivo. In AXL‐driven cancer models, pacDNA inhibits AXL signaling and reduces tumor growth, highlighting the promise of precision polymer scaffolds in aptamer ...
Tingyu Sun, Jiachen Lin, Chenyang Xue, Yuyan Wang, Peiru Chen, Yun Wei, Guobin Xu, Anais Sidonia, Chris Nenopoulos, Hossam Tashkandi, Caroline Shen, Allison Wang, Alex Wang, Ke Zhang   +13 more
wiley   +1 more source