Results 71 to 80 of about 361,534 (336)

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

Suicide and Cardiovascular Death Among Patients With Multiple Primary Cancers in the United States

Frontiers in Cardiovascular Medicine, 2022
BackgroundPrevious studies have demonstrated that patients with a cancer diagnosis have an elevated risk of suicide and cardiovascular death.
Chen Su, Chen Su, Yan Wang, Fang Wu, Yumin Qiu, Yumin Qiu, Jun Tao, Jun Tao   +7 more
doaj   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Loss of m6A Methyltransferase METTL5 Promotes Cardiac Hypertrophy Through Epitranscriptomic Control of SUZ12 Expression

Frontiers in Cardiovascular Medicine, 2022
Enhancement of protein synthesis from mRNA translation is one of the key steps supporting cardiomyocyte hypertrophy during cardiac remodeling. The methyltransferase-like5 (METTL5), which catalyzes m6A modification of 18S rRNA at position A1832, has been ...
Yanchuang Han, Yanchuang Han, Tailai Du, Tailai Du, Siyao Guo, Lu Wang, Gang Dai, Tianxin Long, Tianxin Long, Ting Xu, Ting Xu, Xiaodong Zhuang, Xiaodong Zhuang, Chen Liu, Chen Liu, Shujuan Li, Shujuan Li, Dihua Zhang, Xinxue Liao, Xinxue Liao, Yugang Dong, Yugang Dong, Kathy O. Lui, Xu Tan, Shuibin Lin, Yili Chen, Yili Chen, Zhan-Peng Huang, Zhan-Peng Huang   +28 more
doaj   +1 more source

Genome-Wide Association with Select Biomarker Traits in the Framingham Heart Study [PDF]

, 2007
BACKGROUND: Systemic biomarkers provide insights into disease pathogenesis, diagnosis, and risk stratification. Many systemic biomarker concentrations are heritable phenotypes.
Benjamin, Emelia J., Booth, Sarah L., Dupuis, Josée, Govindaraju, Diddahally R., Kathiresan, Sekar, Keaney, John F., Keyes, Michelle J., Larson, Martin G., Lin, Jing-Ping, Lunetta, Kathryn L., Meigs, James B., Robins, Sander J., Rong, Jian, Schnabel, Renate, Vasan, Ramachandran S., Vita, Joseph A., Wang, Thomas J., Wilson, Peter W. F., Wolf, Philip A.   +18 more
core   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Efficacy and Safety of Nicorandil in Preventing Contrast-Induced Nephropathy after Elective Percutaneous Coronary Intervention: A Pooled Analysis of 1229 Patients

Journal of Interventional Cardiology, 2020
Background. Nicorandil in reducing contrast-induced nephropathy (CIN) following elective percutaneous coronary intervention (PCI) is an inconsistent practice.
Bin Yi, Shaoyan Mo, Yumei Jiang, Dingwu Yi, Jinwen Luo, Xiang Chen, Jian Rong   +6 more
doaj   +1 more source

An Object-Oriented Approach to Knowledge Representation in a Biomedical Domain [PDF]

, 1994
An object-oriented approach has been applied to the different stages involved in developing a knowledge base about insulin metabolism. At an early stage the separation of terminological and assertional knowledge was made. The terminological component was
Ensing, M., Paton, R., Rada, R., Speel, P.H.W.M., Speel, P.H.W.M.   +4 more
core   +2 more sources

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source