Results 101 to 110 of about 3,780,407 (293)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The Gerontologist, 2012 Much has been written about theories of aging in premodern times, but much less is known about theories of residential care. This article describes a handbook prescribing the building, staffing, and running of residences for seniors: The Gerontocomos, published in Italy in 1489 by Gabrielle Zerbi.
openaire +2 more sources
Privacy Perceptions in Ambient Assisted Living
International Conference on Information and Communication Technologies for Ageing Well and e-Health, 2019 Ambient Assisted Living (AAL) Technologies may help address the challenges that the ageing populations pose on the health care systems by supporting older adults in ageing-in-place, improving independence, and quality of care.
Eva-Maria Schomakers, M. Ziefle
semanticscholar +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
The journals of gerontology. Series B, Psychological sciences and social sciences, 2019 OBJECTIVES Investigate black-white disparities in older adults' moves to assisted living and nursing homes and draw from the Andersen Healthcare Utilization Model to test explanations for any disparities.
Meghan Jenkins Morales +1 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Clinical Interventions in Aging, 2021 Ingrid Goudriaan,1,2 Leonieke C van Boekel,1 Marjolein EA Verbiest,1 Joost van Hoof,3,4 Katrien G Luijkx1 1Tranzo, Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, the Netherlands; 2Innovation and Quality, BrabantZorg, Oss ...
Goudriaan I +4 more
doaj
Serious Game iDO: Towards Better Education in Dementia Care
Information, 2019 We describe the iDO serious game developed during implementation of the Innovative Digital Training Opportunities on Dementia for Direct Care Workers (IDO) project.
Rytis Maskeliūnas +6 more
doaj +1 more source
Applications of NILM Techniques to Energy Management and Assisted Living
IFAC-PapersOnLine, 2019 Electricity disaggregation is the process of separating the total electrical load of a single household into appliance specific loads. This can be achieved either by intrusive monitoring of each appliance via individual device load meters or by employing
Álvaro Hernández +4 more
semanticscholar +1 more source