Results 101 to 110 of about 1,514,263 (301)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

NAD+-dependent Sirt6 is a key regulator involved in telomere shortening of in vitro-cultured preimplantation embryos

Communications Biology
Telomere length (TL) is important for maintaining the individual health of a species. Recent studies shows that in vitro fertilization therapy can drastically reduce TL in offspring, however, the underlying molecular mechanism remains unknown. Sirt6 is a
Danjun Li, Wenzhi Li, Xiaoyu Liao, Shutian Jiang, Meng Ma, Zhijie Hu, Kaibo Lin, Weina Yu, Xue Sun, Yong Fan, Haibo Wu, Mingru Yin, Li Wang, Lun Suo, Hui Long, Xuefeng Lu, Yanping Kuang, Qifeng Lyu   +17 more
doaj   +1 more source

Assisted Reproduction: Politics, Ethics and Anthropological Futures

, 2020
Assisted Reproduction: Politics, Ethics and Anthropological ...
T Moll (15824768), FC Ross (15824795)
core  

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

The Positive Assistance of Assisted Reproductive Technology

Epilepsy Currents
Seizure Control in Women With Epilepsy Undergoing Assisted Reproductive Technology Abdulrazaq AA, Ainsworth AJ, Britton JW, Shenoy CC, Babayev SN, Cascino GD, Smith KM. Epilepsia
openaire   +2 more sources

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Assisted Reproduction Conference: Panel 1

, 2003
On Tuesday, January 28, 2003, the Consortium on Law and Values hosted the "Revamping the Law on Assisted Reproduction: From IVF to Surrogate Motherhood" conference.
Consortium on Law and Values in Health, Environment, & the Life Sciences
core  

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Assisted Reproduction Conference: Panel 2

, 2003
On Tuesday, January 28, 2003, the Consortium on Law and Values hosted the "Revamping the Law on Assisted Reproduction: From IVF to Surrogate Motherhood" conference. The second panel discussion featured Kathy Tinglestad, MBA; Sean B. Tipton; Tom
Consortium on Law and Values in Health, Environment, & the Life Sciences
core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source