Results 111 to 120 of about 1,448,946 (300)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Risk factors and treatment strategies for live birth in women with high BMI undergoing ART

BMC Medicine
Background Women with a high BMI represent a growing and challenging population in assisted reproductive technology, as known impairments to treatment outcomes.
Yunhan Nie, Yuting Huang, Zhe Kuang, Mingru Yin, Xi Shen, Yali Liu, Hongyuan Gao, Hui Long, Li Wang   +8 more
doaj   +1 more source

Intramuscular injection of human chorionic gonadotropin as luteal phase support in artificial cycle frozen-thawed embryo transfer does not improve clinical outcomes: a parallel, open-label randomized trial

Frontiers in Endocrinology
BackgroundHuman chorionic gonadotropin (hCG) as one of the first signals secreted by the embryo to the mother may have a direct effect on the endometrium at implantation.
Xiaofang Li, Yu Huang, Yu Huang, Zan Shi, Juanzi Shi, Na Li   +5 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Report of the Commission on Assisted Human Reproduction

, 2005
CAHR ...
Commission on Assisted Human Reproduction
core  

Development and validation of a clinical prediction model for poor ovarian response in assisted reproductive technology

Frontiers in Endocrinology
ObjectiveThe aim of this study was to develop and validate a predictive model for poor ovarian response (POR) in patients undergoing Assisted Reproductive Technology (ART).MethodsThis retrospective cohort study included 1,789 patients who underwent IVF ...
Xin Xin, Xin Xin, Xin Xin, Zhaoxia Cheng, Zhaoxia Cheng, Zhaoxia Cheng, Ting Hu, Ting Hu, Ting Hu, Yi Guo, Yi Guo, Yi Guo, Nan Li, Nan Li, Nan Li, Junbo Zhao, Junbo Zhao, Junbo Zhao, Shuaishuai Guo, Shuaishuai Guo, Shuaishuai Guo   +20 more
doaj   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Nuclear error phenotypes in the two-cell embryo are correlated to blastocyst formation rate after assisted reproduction

PURPOSE: Map the nuclear error phenotypes in the two-cell embryo after assisted reproduction using time lapse images and the effect on good quality blastocyst formation.METHODS: Retrospective cohort study using time lapse images, categorizing 2331 two ...
Stenberg, Amanda,, Adolfsson, Emma,, Baumgart, Juliane,   +2 more
core   +1 more source

Impact of different endometrial preparation protocols on pregnancy outcomes in patients at high risk for ovarian hyperstimulation syndrome: a propensity score matched retrospective cohort study

BMC Pregnancy and Childbirth
Background Few studies have analyzed the endometrial preparation protocols for frozen-thawed embryo transfer (FET) in patients at high risk of ovarian hyperstimulation syndrome (OHSS).
Xu Cao, Caixia Gao, Mingjiao Su, Dian Zhang, Fuyang Zhao, Wentao Li, Pengfei Qu, Juanzi Shi   +7 more
doaj   +1 more source