Results 41 to 50 of about 90,919 (311)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Elective single morula transfer achieved better clinical outcomes than two cleavage embryos transfer in fresh IVF-ET cycles

BMC Pregnancy and Childbirth
Background Assisted reproductive technology (ART) effectively treats infertility yet often results in multiple pregnancies. Optimizing clinical pregnancy rates while minimizing multiples remains challenging.
Qing Feng, Juan Liu, Zhiwei Zhou, Jinbao Ma, Yan Song, Zhaoxia Luo, Xiaohui Ye, Lang Shen   +7 more
doaj   +1 more source

Evaluation of semen DNA integrity and related parameters with COVID-19 infection: a prospective cohort study

Virology Journal, 2023
Background In the context of Corona Virus Disease 2019 (COVID-19) global pandemic, Its impact on male reproductive function should be concerned. Methods Our study is a prospective cohort study that recruited participants infected or uninfected with COVID-
Shuibo Shi, Hongji Hu, Jiayao Wang, Xueming Huang, Jianhao Li, Dongshui Li   +5 more
doaj   +1 more source

ASSISTED HUMAN REPRODUCTION: PSYCHOLOGICAL AND ETHICAL DILEMMAS [PDF]

, 2003
Contributors -- Foreword / Professor Susan Golombok -- Introduction -- Ch. 1. Assisted human reproduction: contemporary policy and practice in the UK / Eric Blytb, Nina Martin and Claire Potter -- Ch. 2. Issues of gamete donation and sex selection: a

core  

Bull sperm selection for assisted reproduction [PDF]

, 2022
The sperm population within an ejaculate is heterogeneous, reflecting differing ability to fertilize an oocyte. Selecting sperm sub-populations with certain desired characteristics may have a positive effect on pregnancy rate in assisted reproduction ...
Kumaresan, Arumugam,, Sveriges lantbruksuniversitet., Morrell, Jane,   +2 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Controlled ovulation of the dominant follicle using progestin in minimal stimulation in poor responders

Reproductive Biology and Endocrinology, 2017
Background The use of progestin (P) during ovarian stimulation is effective in blocking the luteinizing hormone (LH) surge in women with normal ovarian reserve, however, its effects have not been determined in poor responders. This study aimed to explore
Qiuju Chen, Yun Wang, Lihua Sun, Shaozhen Zhang, Weiran Chai, Qingqing Hong, Hui Long, Li Wang, Qifeng Lyu, Yanping Kuang   +9 more
doaj   +1 more source

Telemedicine in assisted reproduction [PDF]

Reproductive BioMedicine Online, 2021
C J, Valdera Simbrón, C, Hernández Rodríguez   +1 more
openaire   +2 more sources