Results 51 to 60 of about 90,919 (311)

Health and development of children born after assisted reproductive technology and sub-fertility compared to naturally conceived children: data from a national study [PDF]

, 2014
In a non-matched case-control study using data from two large national cohort studies, we investigated whether indicators of child health and development up to 7 years of age differ between children conceived using assisted reproductive technology (ART),
Sutcliffe, A., Gardiner, Julian, Jacqueline Barnes, Sutcliffe, Alastair G, Sutcliffe, AG, Gardiner, J, Barnes, Jacqueline, Alastair G. Sutcliffe, Julian Gardiner, Melhuish, Edward C., Melhuish, Edward, Barnes, J, Edward Melhuish   +12 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Intrafollicular soluble receptor for advanced glycation end products (sRAGE) and embryo quality in assisted reproduction [PDF]

, 2013
The developmental potential of human embryos has important implications in assisted reproduction and depends, among other factors, on oocyte competency.
Bonetti, Tatiana C. S. [UNIFESP], Braga, Daniela P. A. F., Iaconelli, Assumpto, Kleine, Joao P. [UNIFESP], Borges, Edson, Silva, Ismael D. C. G. [UNIFESP]   +5 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Effect of estradiol supplementation on luteal support following a significant reduction in serum estradiol levels after hCG triggering: a prospective randomized controlled trial

Reproductive Biology and Endocrinology
Objective This study aimed to evaluate the impact of adding 4 mg estradiol valerate to progesterone for luteal support on pregnancy rates in IVF cycles following a long protocol with reduced luteal serum estradiol levels post-hCG triggering.
Na Li, Yu Huang, LiJuan Fan, Zan Shi, He Cai, JuanZi Shi, Hui Wang   +6 more
doaj   +1 more source

Seasonal variability in the fertilization rate of women undergoing assisted reproduction treatments [PDF]

, 2012
The objective of this study was to evaluate whether seasonality affects human-assisted reproduction treatment outcomes. For this, 1932 patients undergoing intracytoplasmic sperm injection (ICSI) were assigned to a season group according to the day of ...
Savio Figueira, Rita de Cassia, De Almeida Ferreira Braga, Daniela Paes, Borges, Edson [UNESP], Iaconelli, Assumpto, Setti, Amanda   +4 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Does growth hormone supplementation of in vitro fertilization/intracytoplasmic sperm injection improve cumulative live birth rates in women with poor embryonic development in the previous cycle?

Reproductive Biology and Endocrinology
Background Growth hormone (GH) has been proposed as an adjunct in in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles, especially in women with poor ovarian response.
Xitong Liu, Na Li, Dongyang Wang, Wen Wen, Li Tian, Hanying Zhou, Ben W. Mol, Juanzi Shi, Tao Wang   +8 more
doaj   +1 more source

SCN8A p.Arg1872Gln mutation in early infantile epileptic encephalopathy type 13: Review and case report

Biotechnology & Biotechnological Equipment, 2018
Early infantile epileptic encephalopathy (EIEE) is a disorder with variable genetic heterogeneity. Symptoms are mostly presented with generalised epileptic seizures with an infantile onset and progressive neurodevelopmental delay.
Maya Atanasoska, Radoslava Vazharova, Ivan Ivanov, Lubomir Balabanski, Silvia Andonova, Samuil Ivanov, Iliana Pacheva, Maxim Malinov, Draga Toncheva   +8 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source