Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen +15 more
wiley +1 more source
Barriers beyond biology: The socioeconomic and cultural determinants of infertility treatment-seeking behaviour - A systematic review. [PDF]
Chavan R, Joshi S, Kumar R, Barde S.
europepmc +1 more source
Geometry and connectivity are complementary structures, which have demonstrated their ability to represent the brain's functional activity. This study evaluates geometric and connectome eigenmodes as biologically informed constraints for EEG source localization.
Pok Him Siu +6 more
wiley +1 more source
Assisted reproductive technology and reproductive, perinatal, and maternal outcomes: evidence from an umbrella review of systematic reviews with meta-analyses of randomized controlled trials. [PDF]
Wang DD +22 more
europepmc +1 more source
This review highlights recent advancements in stabilizing single metal atoms on graphitic carbon nitride emphasizing innovative synthesis strategies and emerging applications in electrocatalysis, photocatalysis and organic transformations, along with key challenges and future perspective. Abstract Emerging as a new frontier in catalysis science, single‐
Wenyao Zhang +6 more
wiley +1 more source
Electrical Stimulation Directs Formation of Perfused Vasculature in Engineered Tissues
Electrical stimulation (ESTIM) enhances vasculature formation in engineered human tissues. In 3D endothelial‐fibroblast constructs, conditioning with ESTIM promotes the formation of dense and highly branched networks that rapidly anastomose with mouse vasculature when implanted in vivo. Vessels formed under ESTIM are importantly functionally perfusable.
Katarzyna A. Grzelak +6 more
wiley +1 more source
Being (a) patient-navigating desire through online communities in assisted reproductive technology. [PDF]
Decataldo A, Andreoni E.
europepmc +1 more source
Non-invasive biomechanical characterization of embryos using microfluidic cantilevers. [PDF]
Turnbull IC +4 more
europepmc +1 more source
Testicular microlithiasis and male fertility: a dual perspective integrating imaging and physiological insights. [PDF]
Zhou J, Hu S, Ouyang Y, Liu M.
europepmc +1 more source

