Results 121 to 130 of about 6,500,274 (300)

Assisted reproductive technologies and human rights [PDF]

, 2014
[Extract] Assisted reproductive technologies (ART) have challenged our thinking around what it means to be human. Associated with this is the dignity and humanity in a decision to become a parent, and how our genetic material is to be used.
Galloway, Kate
core   +1 more source

2015 Assisted Reproductive Technology Report \u2014 Graphs and Charts

Graphs and charts from the 2015 Assisted Reproductive Technology National Summary Report provide an in-depth picture of the type, number, and outcome of ART cycles performed in U.S. fertility clinics.

core  

2018 Assisted Reproductive Technology Fertility Clinic Success Rates Report [PDF]

The ART report provides an in-depth picture of the type, number, and outcome of ART cycles performed in U.S. fertility clinics. It includes individual clinic tables with ART success rates for 456 fertility clinics in operation in 2018 that provided and ...

core  

Intrafollicular soluble receptor for advanced glycation end products (sRAGE) and embryo quality in assisted reproduction

, 2013
The developmental potential of human embryos has important implications in assisted reproduction and depends, among other factors, on oocyte competency.
Bonetti, Tatiana C. S. [UNIFESP], Braga, Daniela P. A. F., Iaconelli, Assumpto, Kleine, Joao P. [UNIFESP], Borges, Edson, Silva, Ismael D. C. G. [UNIFESP]   +5 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Is hysteroscopy a routine investigation before assisted reproductive techniques?

Caspian Journal of Reproductive Medicine, 2015
Introduction: Infertility is a common problem as it is observed in 10 - 15% of couples to whom developing approaches for treatment is an issue of utmost importance.
Maryam Javadian, Seddigheh Esmaeilzadeh, Mehrnaz Farzadmanesh, Masoumeh Golsorkhtabar- Amiri   +3 more
doaj   +2 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source