Results 51 to 60 of about 6,814,669 (306)

Hope and exploitation in commercial provision of assisted reproductive technologies [PDF]

, 2023
Innovation is a key driver of care provision in Assisted Reproductive Technologies (ART). ART providers offer a range of ‘add-on’ interventions, aiming to augment standard IVF protocols and improve the chances of a live birth. Particularly in the context
Lipworth, Wendy, Watts, Gabe, Newson, Ainsley, Wrigley, Anthony   +3 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Impact of ovarian hyperstimulation syndrome on intracytoplasmic sperm injection outcomes in poly-cystic ovarian syndrome women: A cross-sectional study

International Journal of Reproductive BioMedicine
Background: Polycystic ovarian syndrome (PCOS) is a complex disorder that affects the endocrine, metabolic, and reproductive systems. While controlled ovarian hyperstimulation can increase the number of oocytes retrieved and improve the number of good ...
Mufeda Ali Jwad, Maryam Hussein Khaleefah, Ramih Abd AlFattah Naser   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Ethical objections to sex selection for nonmedical reasons [PDF]

, 2008
This paper examines the main ethical argument used to support the use of sex selection for non-medical reasons, namely that sex selection for non-medical reasons should be allowed on the grounds of reproductive autonomy.
Frith, Lucy; id_orcid, Crawshaw, Marilyn, Blyth, Eric, Frith, Lucy   +3 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A novel technique- subendometrial autologous platelet rich plasma injection in patients with unresponsive thin endometrium undergoing frozen-thawed embryo transfer: a prospective cohort study

BMC Pregnancy and Childbirth
Background The purpose of this study was to investigate the effects of subendometrial PRP injection on endometrial thickness and pregnancy outcomes in patients with a history of unresponsive thin endometrium undergoing frozen-thawed embryo transfer (FET).
Yigit Cakiroglu, Yusuf Aytac Tohma, Aysen Yuceturk, Ozge Karaosmanoglu, Ilke Ozer Aslan, Sule Yildirim Kopuk, Zeynep Ece Utkan Korun, Caglar Yazicioglu, Hulusi Bulent Zeyneloglu, Bulent Tiras   +9 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Changes in Ovarian Functions Following Platelet-Rich Plasma (PRP) Injection and Its Impact on in Vitro Fertilisation (IVF) Treatment: A Pre-Post Research

Clinical and Experimental Obstetrics & Gynecology
Background: Giving birth is one of the challenges that women of reproductive age encounter when their ovarian reserve has decreased or been lost.
Serap Simavlı, Emel Kiyak Caglayan, Ikbal Kaygusuz, Fatih Albayrak, Eray Caliskan   +4 more
doaj   +1 more source