Results 91 to 100 of about 9,404,323 (308)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Assisted reproductive technology: prevalence and associated factors in Southern Brazil
Revista de Saúde Pública, 2019 OBJECTIVE: To assess the prevalence of successful assisted reproductive technology and to identify the associated factors. METHODS: This population-based birth cohort study was carried out with 4,333 pregnant women expected to deliver in 2015 in the ...
Shana Ginar da Silva +5 more
doaj +1 more source
2011 Assisted Reproductive Technology National Summary Report [PDF]
The data for this national report come from the 451 fertility clinics in operation in 2011 that provided and verified data on the outcomes of all ART cycles started in their clinics.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
2015 Assisted Reproductive Technology National Summary Report [PDF]
The data for this national report come from the 464 fertility clinics in operation in 2015 that provided and verified data on the outcomes of all ART cycles started in their clinics. Of the 231,936 ART cycles performed in 2015 at these reporting clinics,
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
2018 Assisted Reproductive Technology National Summary Report [PDF]
The data for this national report come from the 456 US fertility clinics in operation in 2018 that provided and verified data on the outcomes of all ART cycles started in their clinics.
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Health and development of children born after assisted reproductive technology and sub-fertility compared to naturally conceived children: data from a national study [PDF]
, 2014 In a non-matched case-control study using data from two large national cohort studies, we investigated whether indicators of child health and development up to 7 years of age differ between children conceived using assisted reproductive technology (ART),
Sutcliffe, A. +12 more
core +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
2012 Assisted Reproductive Technology National Summary Report [PDF]
The data for this national report come from the 456 fertility clinics in operation in 2012 that provided and verified data on the outcomes of all ART cycles started in their clinics. Of the 176,247 ART cycles performed in 2012 at these reporting clinics,
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