Results 61 to 70 of about 175,226 (339)

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Estimating the burden of disease attributable to non-assisted suicide in Switzerland from 2009 to 2021: a secondary data analysis

Swiss Medical Weekly
CONTEXT AND GOAL: This research addresses the issue of suicide and attempted suicide, which have a significant impact on global premature mortality and disability.
Annora Mack, Sarah Rajkumar, Jacob Kofler, Kaspar Wyss   +3 more
doaj   +1 more source

Attitudes about withholding or withdrawing life-prolonging treatment, euthanasia, assisted suicide, and physician assisted suicide: a cross-sectional survey among the general public in Croatia

BMC Medical Ethics, 2022
Background There has been no in-depth research of public attitudes on withholding or withdrawing life-prolonging treatment, euthanasia, assisted suicide and physician assisted suicide in Croatia.
Ana Borovecki, Marko Curkovic, Krunoslav Nikodem, Stjepan Oreskovic, Milivoj Novak, Filip Rubic, Jurica Vukovic, Diana Spoljar, Bert Gordijn, Chris Gastmans   +9 more
doaj   +1 more source

Assisted Suicide and Euthanasia: Arguing for a Distinction [PDF]

, 2004
In this essay, I will try to analyze the problems of assisted suicide and euthanasia by using the Joel Feinberg’s analysis of the so-called ‘right to life’ and the Wesley Hohfeld’s legal terminology.
Del Bò, Corrado
core   +1 more source

A Glucose‐Responsive Intelligent Antibacterial and Oxygen‐Producing Hydrogel Promotes the Healing of Diabetic Wounds by Regulating Cellular Heterogeneity

Advanced Science, EarlyView.
We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu, Zhongcheng Li, Qian Ren, Ziqian Lu, Yubing Zhang, Yili Guo, Ruomeng Li, Die Hu, Linglin Zhang   +8 more
wiley   +1 more source

Increase in assisted suicide in Switzerland: did the socioeconomic predictors change? Results from the Swiss National Cohort

BMJ Open, 2018
Objective To determine whether the strong increase in assisted suicides in Switzerland since 2008 is linked to a shift in the socioeconomic factors associated with assisted suicide and its related diagnoses.Methods In a population-based longitudinal ...
Marcel Zwahlen, Nicole Steck, Christoph Junker   +2 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

May Christians request medically assisted suicide and euthanasia?

HTS Teologiese Studies/Theological Studies, 2016
The article deals with the question: ‘Is it morally acceptable for terminally ill Christians to voluntarily request medically assisted suicide or euthanasia?’ After a brief discussion of relevant changes in the moral landscape over the last century, two ...
D. Etienne de Villiers
doaj   +1 more source

Introductory Remarks of Panel II: Legal, Medical, and Ethical Considerations for the Future of Physician-Assisted Suicice Symposium: Physician-Assusted Suicide: Legal Rights in Life and Death: Introductory Remarks of Panel II: Legal, Medicial, and Ethical Considerations for the Future of Physician-Assisted Suicide [PDF]

, 1996
Once the Supreme Court issues it decision in the cases of Quill v. Vacco1 and Compassion in Dying v. Washington2 regarding the constitutionality of outlawing physician-assisted suicide for competent and terminally ill persons, the tension surrounding ...
Hernandez, Tanya K.
core   +1 more source

Clinical problems with the performance of euthanasia and physician-assisted suicide in The Netherlands [PDF]

, 2000
BACKGROUND AND METHODS: The characteristics and frequency of clinical problems with the performance of euthanasia and physician-assisted suicide are uncertain. We analyzed data from two studies of euthanasia and physician-
Groenewoud, J.H. (Hanny), Heide, A. (Agnes) van der, Maas, P.J. (Paul) van der, Onwuteaka-Philipsen, B.D. (Bregje), Wal, G. (Gerrit) van der, Willems, D.L. (Dick)   +5 more
core   +2 more sources