Results 41 to 50 of about 91,460 (267)

Re-thinking technology and its growing role in enabling patient empowerment [PDF]

, 2018
© The Author(s) 2018. The presence and increase of challenges to eHealth in today’s society have begun to generate doubts about the capability of technology in patient empowerment, especially within the frameworks supporting empowerment.
Akeel, Aisha Umar, Mundy, Darren
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A Universalist strategy for the design of Assistive Technology [PDF]

, 2012
Assistive Technologies are specialized products aiming to partly compensate for the loss of autonomy experienced by disabled people. Because they address special needs in a highly-segmented market, they are often considered as niche products.
AOUSSAT, Améziane, BUISINE, Stéphanie, DUMAS, Claude, MANTELET, Fabrice, PLOS, Ornella   +4 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

A systematic review of the utility of assistive technologies for SEND students in schools

Frontiers in Education
The systematic review investigates the effect of various educational technologies on the learning outcomes of diverse student populations, particularly focusing on assistive technology interventions for students with disabilities.
Kaussar Mukhtarkyzy, Laura Smagulova, Ainur Tokzhigitova, Nurgul Serikbayeva, Olzhas Sayakov, Asset Turkmenbayev, Rakhila Assilbayeva   +6 more
doaj   +1 more source

Development of Assistive Robots Using International Classification of Functioning, Disability, and Health: Concept, Applications, and Issues

Journal of Robotics, 2013
Many assistive robots for elderly and disabled people have been developed in the past few decades. However, very few of them became commercially available.
Hideyuki Tanaka, Masahiro Yoshikawa, Eimei Oyama, Yujin Wakita, Yoshio Matsumoto   +4 more
doaj   +1 more source

Implications of the Information Technology Revolution for People with Disabilities [PDF]

, 2000
The paper focuses on opportunities for the integration of persons with different types of disabilities in the information technology (IT) labour market.
Bonney, Martha, Bruyere, Susanne M, Dr., Ruiz-Quintanilla, S. Antonio   +2 more
core   +1 more source

Disability-aware adaptive and personalised learning for students with multiple disabilities [PDF]

, 2017
Purpose The purpose of this paper is to address how virtual learning environments (VLEs) can be designed to include the needs of learners with multiple disabilities.
Brayshaw, Mike, Nganji, Julius T.
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source