Results 51 to 60 of about 91,889 (285)

Re-thinking technology and its growing role in enabling patient empowerment [PDF]

, 2018
© The Author(s) 2018. The presence and increase of challenges to eHealth in today’s society have begun to generate doubts about the capability of technology in patient empowerment, especially within the frameworks supporting empowerment.
Akeel, Aisha Umar, Mundy, Darren
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Effects of brain-computer interface based training on post-stroke upper-limb rehabilitation: a meta-analysis

Journal of NeuroEngineering and Rehabilitation
Background Previous research has used the brain-computer interface (BCI) to promote upper-limb motor rehabilitation. However, the results of these studies were variable, leaving efficacy unclear. Objectives This review aims to evaluate the effects of BCI-
Dan Li, Ruoyu Li, Yunping Song, Wenting Qin, Guangli Sun, Yunxi Liu, Yunjun Bao, Lingyu Liu, Lingjing Jin   +8 more
doaj   +1 more source

A systematic review of the utility of assistive technologies for SEND students in schools

Frontiers in Education
The systematic review investigates the effect of various educational technologies on the learning outcomes of diverse student populations, particularly focusing on assistive technology interventions for students with disabilities.
Kaussar Mukhtarkyzy, Laura Smagulova, Ainur Tokzhigitova, Nurgul Serikbayeva, Olzhas Sayakov, Asset Turkmenbayev, Rakhila Assilbayeva   +6 more
doaj   +1 more source

Improve Access to Assistive Technologies and Promote Universal Health Coverage

Xiehe Yixue Zazhi, 2022
Assistive technology is a subset of health technology. The resolution on improving access to assistive technology adopted by the 71st World Health Assembly illustrates that it is extremely important to integrate assistive technologies into healthcare ...
DONG Liquan, LIU Zhihong, XIE Ganlin, LI Yanyu   +3 more
doaj   +1 more source

Documenting Downloadable Assistive Technologies [PDF]

, 2016
This major research project explores Downloadable Assistive Technologies (DAT) and the possibilities as well as the limitations of publishing and fabricating DAT through online 3D printing communities. A design probe was used for this research within the
Charbonneau, Erica
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Therapeutic robots for post-stroke rehabilitation

Medical Review
Stroke is a prevalent, severe, and disabling health-care issue on a global scale, inevitably leading to motor and cognitive deficits. It has become one of the most significant challenges in China, resulting in substantial social and economic burdens.
Hong Ronghua, Li Bingyu, Bao Yunjun, Liu Lingyu, Jin Lingjing   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source