Results 81 to 90 of about 8,248,213 (296)

Pushing the limit to near real-time indoor LiDAR-based semantic segmentation [PDF]

open access: yesThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Semantic segmentation of indoor 3D point clouds is a critical technology for understanding three dimensional indoor environments, with significant applications in indoor navigation, positioning, and intelligent robotics.
P. Bournez   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Brain activity during cognitive-motor tasks in older adults with cognitive frailty: a fNIRS study

open access: yesFrontiers in Aging Neuroscience
BackgroundCognitive frailty has recently drawn increasing attention in the context of elderly healthcare. While structural brain alterations in older adults with cognitive frailty have been previously explored, functional brain changes particularly ...
Yin-Hsiang Wang   +4 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Improving Assistive Technology in Practice: Contributions From Interdisciplinary R&D Collaboration

open access: yes, 2019
This paper describes a collaborative strategy shared by a rehabilitation center and a public university with a goal to improve the knowledge on assistive technology and rehabilitation research and development in Brazil.
da Silva, Sara Raquel Martins   +3 more
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Financing options for the provision of assistive products

open access: yes, 2021
Having predictable, stable and adequate financial resources is essential for achieving universal coverage of essential health products and services, including assistive products.
Bell, Diane   +2 more
core   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Assistive technology: opportunities and implications [PDF]

open access: yes, 2009
It is important to recognize the role of technology and the impact on the lives of people who mostly do not understand how much this technology is already shaping the future.
Soar, Jeffrey   +2 more
core   +1 more source

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