Results 41 to 50 of about 46,885 (304)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Assistive technology pricing: is it fair and reasonable? [PDF]

open access: yes, 2014
Concerns about the price of assistive technology products (AT, also known as aids and equipment) arise regularly in public policy discourse and the media.
Michael Summers, Chris Sparks
core  

Psychosocial impact of mobility assistive technology on people with neurological conditions

open access: yes, 2020
ntroduction: A wide range of products are available to assist mobility, and it is, therefore, of great importance to obtain empirical information regarding the expected impact of the use of these products based on outcome measures.
Ordóñez Fernández, Feliciano Francisco   +3 more
core   +1 more source

Discernment on assistive technology for the care and support requirements of older adults and differently-abled individuals

open access: yesFrontiers in Public Health, 2023
Assistive technology for the differently abled and older adults has made remarkable achievements in providing rehabilitative, adaptive, and assistive devices.
P. Muthu   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Assistive Technology in Education

open access: yesThe International Journal of Information, Diversity, & Inclusion, 2021
This article offers a socio-technical framing of assistive technology design for in-classroom use to enable a better understanding of how to improve educational opportunities and outcomes for learners with disabilities. By addressing social inequities in
Vanesa Ayon, Andrew Dillon
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Review of intensive assessment recommendations conducted at the Assistive Technology and Assessment Center (ATAC), University of Wisconsin--Stout [PDF]

open access: yes, 2001
Plan BThe 1990s brought change to the field of rehabilitation via two pieces of legislation. The first, Americans with Disabilities Act in 1990, added reasonable accommodation to the forefront of service delivery and employment.
Miess, Karla Jo
core  

Assistive technology as a pillar of universal health coverage : qualitative analysis of stakeholder responses to the world health assembly resolution on assistive technology

open access: yes, 2020
The importance of assistive technology (AT) as a pillar of universal health coverage was recognized at the 71st World Health Assembly (WHA) through the passing of Resolution 71.8 on improving access to AT (May 2018).
Steel, Emily   +9 more
core   +1 more source

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