Results 251 to 260 of about 15,138,687 (296)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dissecting the Genetic Basis of Low Back Pain Independent of BMI Through Genomic Structural Equation Modeling. [PDF]

J Pain Res
Huo L, Tan L, Wang F, Sun J, Niu Y, Jiang Y, Wu M, Shi J, Hao Y, Wang J, Huang S, Chen Z.   +11 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Association between oral microbiota and inflammatory bowel disease: A 2-sample Mendelian randomization study in East Asian populations. [PDF]

Medicine (Baltimore)
Xie RX, Ci XY, Xue YB, Liu M, Zhang MJ.
europepmc   +1 more source

Migraines and the association of cognitive impairment: a one- and two-sample mendelian randomization analysis. [PDF]

Dialogues Clin Neurosci
Bai CH, Fan HY, Lin HA, Lin SF.
europepmc   +1 more source

Sleep, Physical Activity, and Mood Among People Seeking Mental Health Care.

JAMA Netw Open
Kulshreshtha A, Fang Y, Mills ED, Bohnert ASB, Sen S.   +4 more
europepmc   +1 more source

Associations between physical activity, fitness, cognitive and academic performance in Swedish adolescents: Findings from a cross-sectional study. [PDF]

PLoS One
Kjellenberg K, Wang R, Horre JN, Helgadóttir B, Ekblom Ö, Singh A, Nyberg G.   +6 more
europepmc   +1 more source

Systemic inflammatory response index is associated with acute kidney injury following cardiac surgery: A retrospective cohort study using the MIMIC database. [PDF]

PLoS One
Xie H, Zheng K, Wang K, Zhao Z, Si R, Xiao J, Yin Y, Zhu X.   +7 more
europepmc   +1 more source

Phosphatidylinositol 4,5-bisphosphate mediates Arl4D self-interaction to promote Pak1 signaling. [PDF]

Proc Natl Acad Sci U S A
Chang TW, Lee FS.
europepmc   +1 more source

Metabolic syndromes mediate the association between depression and cardiovascular diseases in the UK Biobank Population Study. [PDF]

Compr Psychoneuroendocrinol
Lan T, Zhu Y, Cai G, Pan F, Wang M.
europepmc   +1 more source