Results 251 to 260 of about 33,166,918 (299)

Genome-wide association analysis identifies the genetic basis of body size traits in Tan sheep (Ovis aries). [PDF]

BMC Genomics
Ding W, Yang Y, Ma X, Yue C, Jia L, Tian J, Chen X, Niu Z, Ma Y, Sun M, EEr H.   +10 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Identification of key candidate genes for body weight traits in male Dongfeng sika deer based on genome-wide association analysis. [PDF]

Sci Rep
Zhang X, Zhang Y, Zhao L, Zhao Y, Qian WX, Gai G, Song J, Du P, Han H, Zhang Z.   +9 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Computation and resource efficient genome-wide association analysis for large-scale imaging studies. [PDF]

Nat Commun
Jiang Z, Stein J, Li T, Fang E, Li Y, Sullivan P, Zhu H.   +6 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Genome-wide association analysis reveals genetic variations and candidate genes associated with tannin and starch contents in sorghum. [PDF]

BMC Genomics
Fan X, Liang D, Wang C, Zhang Y, Guo Q, Wang H, Li C, Shen X, Liu Q, Xu P.   +9 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A comparative genomic approach to identify determinants of meropenem resistance in <i>Klebsiella pneumoniae</i> using pan-genome-wide association analysis. [PDF]

Front Microbiol
Vijayakumar S, Ramaiah S.
europepmc   +1 more source

Machine learning-based genome-wide association analysis to construct a clinical decision model for severe neonatal jaundice. [PDF]

Transl Pediatr
Ma H, Chen X, Zhang P, Dong X, Wu B, Chen G, Zhou W, Wang M.   +7 more
europepmc   +1 more source