Results 1 to 10 of about 5,568,459 (279)
The CRISPR/Cas9 system is a powerful tool for gene repair that holds great potential for gene therapy to cure monogenic diseases. Despite intensive improvement, the safety of this system remains a major clinical concern.
Ngoc Tung Tran +5 more
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Median Distance Model for Likert-Type Items in Contingency Table Analysis
Likert-type items (questions) are a widely used scale in questionnaire design. The “neutral” or “undecided” option may lead to misinterpretation and confusion about the results.
Serpil Aktas Altunay +1 more
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Using passive water collection strategies, La Maraña and ARECMA, together with the community of Mariana, design and construct an autonomous emergency water supply system, crystallizing decades of struggle for the right to water in the face of a fragile ...
Francisco Susmel, La Maraña, ARECMA
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A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation
IntroductionThe differentiation of B cells into antibody-secreting plasma cells depends on cell division-coupled, epigenetic and other cellular processes that are incompletely understood.MethodsWe have developed a CRISPR/Cas9-based screen that models an ...
Ermeng Xiong +8 more
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Affective Neuroscience: The Suitability of a Web App to Monitor Affective States at Work
This work describes in detail the use of a new tool, a web-app, based on the conceptual framework of affective neuroscience, in particular on Panksepp’s 7 basic emotional systems.
Paola Manfredi +2 more
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Advances in the regenerative stem cell field have propelled the generation of tissue-specific cells in the culture dish for subsequent transplantation, drug screening purposes, or the elucidation of disease mechanisms.
Parivash Nouri +5 more
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The brown alga Ectocarpus has a haploid-diploid life cycle that involves alternation between two multicellular generations, the sporophyte and the gametophyte.
Haiqin Yao +8 more
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Association Between Platelet-to-Lymphocyte Ratio and Preterm Necrotizing Enterocolitis
Introduction: Necrotizing enterocolitis (NEC) is a fatal condition for very-low-birth-weight infants. Necrotizing enterocolitis is a multi-factor phenomenon that results in intestinal mucosal damage and leads to intestinal necrosis.
Juan Zheng +4 more
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Two-stage two-locus models in genome-wide association. [PDF]
Studies in model organisms suggest that epistasis may play an important role in the etiology of complex diseases and traits in humans. With the era of large-scale genome-wide association studies fast approaching, it is important to quantify whether it ...
David M Evans +3 more
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Stochastic models (cooperative and non-cooperative) for NMR analysis of the hetero-association of aromatic molecules in aqueous solution [PDF]
Stochastic cooperative (STOCH-C) and non-cooperative (STOCH-NC) models have been developed for NMR analysis of the hetero-association of aromatic compounds in solution, in order to take into account all physically meaningful association reactions of ...
Davies, David B. +2 more
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