Results 51 to 60 of about 29,374,400 (314)

Weighted functional linear regression models for gene-based association analysis.

PLoS ONE, 2018
Functional linear regression models are effectively used in gene-based association analysis of complex traits. These models combine information about individual genetic variants, taking into account their positions and reducing the influence of noise and/
Nadezhda M Belonogova, Gulnara R Svishcheva, James F Wilson, Harry Campbell, Tatiana I Axenovich   +4 more
doaj   +1 more source

MYCN Amplification in RB1‐Inactivated Retinoblastoma: Association With High‐Risk Features

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background MYCN amplification occurs in a subset of retinoblastoma cases, both with and without RB1 inactivation. It has been suggested that retinoblastomas with MYCN amplification represent a distinct entity with more aggressive clinical behavior.
Kyriaki Papaioannou, Regina Kubica, Karen Fischhuber, Jasmin Beygo, Madlen Reschke, Petra Ritter‐Sovinz, Eva Biewald, Petra Ketteler, Dietmar Lohmann, Deniz Kanber   +9 more
wiley   +1 more source

Epicoccin A Ameliorates PD-like Symptoms in Zebrafish: Enhancement of PINK1/Parkin-Dependent Mitophagy and Inhibition of Excessive Oxidative Stress

Marine Drugs
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, yet effective agents for its prevention and therapy remain highly limited.
Haicheng Ye, Dan Li, Lei Zhang, Yufei Wang, Cong Wang, Meng Jin, Houwen Lin, Peihai Li, Chen Sun, Ning Li   +9 more
doaj   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

From theory to practice in training health researchers in patient and public involvement: a scoping review protocol

Systematic Reviews
Background Patient and public involvement (PPI) aims to increase the relevance and impact of research by ensuring that outcomes align with the real needs of those involved.
Caline Jesus, Isabelly Cristina Rodrigues Regalado, Karolinne Souza Monteiro, Adriana Gomes Magalhães, Paula Silva de Carvalho Chagas, Christina D. C. M. Faria, Vanessa Vega Córdova, Izaskun Álvarez-Aguado, Eve Namisango, Christopher Morris, Egmar Longo   +10 more
doaj   +1 more source

Comparison of genome-wide association methods in analyses of admixed populations with complex familial relationships. [PDF]

PLoS ONE, 2014
Population structure is known to cause false-positive detection in association studies. We compared the power, precision, and type-I error rates of various association models in analyses of a simulated dataset with structure at the population (admixture ...
Naveen K Kadri, Bernt Guldbrandtsen, Peter Sørensen, Goutam Sahana   +3 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Inclusive and Enjoyable Physical Activity for Older Adults: The JOIN4JOY Project

Baltic Journal of Sport and Health Sciences
Purpose: Older adults remain the least physically active group in Europe, with barriers such as low socioeconomic status, health limitations, and social exclusion contributing to inactivity.
Erika Karkauskienė, Laura Coll-Planas, Andrea Fuente-Vidal, Javier Jerez-Roig, Montse Romero-Mas, Paolo Caserotti, Mathias Skjødt, Dhayana Dallmeier, Guillaume Lefebvre, Lucie Bassinah, Dolores Forgione, Ricard Castro-Prat, Eduard Minobes-Molina, Sergi Blancafort Alias, Blanca Roman-Viñas, José Luis Socorro-Cumplido, Ainhoa Nieto-Guisado, Oriol Sansano-Nadal, Maria Giné-Garriga   +18 more
doaj   +1 more source

Rehabilitation for children with chronic acquired brain injury in the Child in Context Intervention (CICI) study: study protocol for a randomized controlled trial

Trials, 2022
Background Pediatric acquired brain injury (pABI) is associated with long-term cognitive, behavioral, social, and emotional problems, which may affect the quality of life, school, and family functioning.
Nina Rohrer-Baumgartner, Ingvil Laberg Holthe, Edel Jannecke Svendsen, Cecilie Røe, Jens Egeland, Ida M. H. Borgen, Solveig L. Hauger, Marit V. Forslund, Cathrine Brunborg, Hege Prag Øra, Hilde Margrete Dahl, Line Kildal Bragstad, Eli Marie Killi, Maria Sandhaug, Ingerid Kleffelgård, Anine Pernille Strand-Saugnes, Ingeborg Dahl-Hilstad, Jennie Ponsford, Laraine Winter, Shari Wade, Marianne Løvstad   +20 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source